岭南现代临床外科2024，Vol.24Issue(6)：378-383,6.DOI:10.3969/j.issn.1009-976X.2024.06.007
脑脊液中IL-17A表达与交通性脑积水患者临床预后的分析
IL-17A as a potential prognostic biomarker in communicating hydrocephalus patients
摘要
Abstract
Objective This study aimed to explore the predictive value of preoperative cerebrospinal fluid(CSF)interleukin-17a(IL-17A)levels for the clinical prognosis of patients with communicating hydrocephalus.Methods This study retrospectively analyzed the clinical data of 54 patients with com-municating hydrocephalus admitted to the Department of Neurosurgery of the Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine from January 2019 to December 2023.All selected patients underwent lumbar puncture before surgery to collect CSF samples for IL-17A level detection.The clinical efficacy of the patients was evaluated using the National Institutes of Health Stroke Scale(NIHSS)at 4 weeks and 3 years after surgery,and the potential relationship between CSF IL-17A levels and clini-cal efficacy was analyzed.Results The study data showed that patients with more severe preoperative symptoms had higher IL-17A expression levels in CSF.In the efficacy assessment at 4 weeks after surgery,90.7%of the patients showed significant improvement in symptoms,but the association between CSF IL-17A levels and immediate postoperative efficacy was not significant.However,in the long-term efficacy assessment at 3 years after surgery,the NIHSS scores of the patients were significantly lower than those before surgery,and the CSF IL-17A levels of patients with better treatment efficacy were significantly lower than those with poorer efficacy(P<0.05).Additionally,the study indicated that patients with adverse reactions had significantly higher IL-17A expression levels in CSF than those without adverse reactions.Conclusion This study demonstrated that the expression level of IL-17A in CSF can serve as an effective indicator for predicting the long-term clinical prognosis of patients with communicating hydrocephalus.This finding provides a new perspective and potential intervention target for the clinical treatment of communicating hydrocephalus.关键词
白介素17A/交通性脑积水/临床疗效Key words
Interleukin-17A/communicating hydrocephalus/clinical efficacy分类
医药卫生引用本文复制引用
林海,叶忠兴,林玲,胡瑜玲,王蕊,张文静,唐文龙..脑脊液中IL-17A表达与交通性脑积水患者临床预后的分析[J].岭南现代临床外科,2024,24(6):378-383,6.基金项目
福建省自然科学基金计划项目(2022J01121051) （2022J01121051）
