岭南现代临床外科2024，Vol.24Issue(6)：398-409,12.DOI:10.3969/j.issn.1009-976X.2024.06.011
肿瘤微环境介导代谢重编程在前列腺癌中的研究进展
Tumor microenvironment-mediated metabolic reprogramming in prostate cancer:from mecha-nisms to therapeutics
摘要
Abstract
Metabolic reprogramming plays a key role in the progression of prostate cancer.In addition to tumor DNA mutation and epigenetics,the complicated crosstalk between tumor microenvironment and tumor cells is an important factor driving metabolic reprogramming of prostate cancer,leading to cancer progression and treatment failure.The continuous interaction between tumor cells and immune cells(such as macrophages,lymphocytes and natural killer cells),non-immune cells(such as fibroblasts and endothelial cells),extracellular matrix components and soluble factors in the tumor microenvironment leads to metabolic competition and symbiosis,inducing metabolic reprogramming of tumor cells,and remodeling the metabolic characteristics of neighboring cells at the same time,which ultimately leads to the development of prostate cancer.Targeting metabolic reprogramming of prostate cancer in microenvi-ronment is a promising strategy to improve prostate cancer treatment dilemmas.In this review,we focus on the current studies of microenvironment-mediated metabolic reprogramming in prostate cancer,which can improve the understanding of the mechanisms that metabolic reprogramming regulates prostate cancer progression,and may shed light on new therapeutic strategies targeting metabolic reprogramming for pros-tate cancer patients.关键词
前列腺癌/代谢重编程/肿瘤微环境/靶向治疗Key words
prostate cancer/metabolic reprogramming/tumor microenvironment/targeted therapy分类
医药卫生引用本文复制引用
李栋泉,黄山河,黄海,谢锐辉..肿瘤微环境介导代谢重编程在前列腺癌中的研究进展[J].岭南现代临床外科,2024,24(6):398-409,12.基金项目
国家自然科学基金(82473014 （）
82472902) （）
