西南医科大学学报2025，Vol.48Issue(1)：11-16,6.DOI:10.3969/j.issn.2096-3351.2025.01.003
复方中药干预代谢相关脂肪性肝病的研究进展
Research Progress on the Intervention of Metabolic Associated Fatty Liver Disease with Compound Traditional Chinese Medicine
摘要
Abstract
Metabolic associated fatty liver disease(MAFLD)has become a global health problem,so far,few drugs have been approved for marketing,and its complex pathogenesis has led to great challenges in drug development.In this paper,the current status of MAFLD drug research and development at home and abroad,as well as the clinical research and new drug development of compound Chinese medicine in the treatment of MAFLD were summarized.Through the basic research of compound Chinese medicine,it was found that compound Chinese medicine could improve lipid metabolism,reduce inflammation and fibrosis,and regulate intestinal microflora through comprehensive intervention of multi-target and multi-pathway regulation.It is suggested that compound Chinese medicine may be one of the potential new drug development fields for MAFLD treatment in the future.This article reviewed the intervention of metabolic-related fatty liver disease with compound traditional Chinese medicine,aiming to provide a reference for clinical practice.关键词
代谢相关脂肪性肝病/药物研发/中医药/机制/靶点Key words
MAFLD/Drug development/TCM/Mechanisms/Targets分类
中医学引用本文复制引用
孙屿昕,童光东..复方中药干预代谢相关脂肪性肝病的研究进展[J].西南医科大学学报,2025,48(1):11-16,6.基金项目
广东省基础与应用基础研究基金区域联合基金重点项目(2022B1515120034) （2022B1515120034）
广东省横琴重点实验室(HQCML-C-2024007) （HQCML-C-2024007）
深圳市中医肝病重点实验室(ZDSYS20210623092000002) （ZDSYS20210623092000002）
三九企业横向项目(202013) （202013）
