饲料研究2024，Vol.47Issue(22)：73-77,5.DOI:10.13557/j.cnki.issn1002-2813.2024.22.013
艳山姜纯露对啤酒酵母致热家兔的解热作用及下丘脑NF-κB表达的影响
Effects of dewdrops from Aplinia zerubet fruits and on antipyretic and hypothalamus NF-κB expression in brewer's yeast-induced fever rabbits
摘要
Abstract
The experiment aimed to investigate the antipyretic effects of dewdrops from Aplinia zerubet fruits(DAF)and effects on hypothalamus NF-κB expression in fever rabbits induced by brewer's yeast.60-day-old rabbits except rabbits in control group were subcutaneously injected with brewer's yeast(135 mg/kg)into their back of neck to establish the fever models,and five hours after modeling,30 rabbits with anal temperature gain 0.8～3.0℃were randomly divided into five groups.Rabbits in control group and model group were intragastrically fed with pure water,rabbits in ibuprofen group were intragastrically fed with dose of ibuprofen suspension 10 mg/kg,and rabbits in group DAF1,DAF2,DAF3 were intragastrically fed with dose of 1.8,3.6,7.2 g/kg DAF.The results showed that compared with the model group,the DAF2 and DAF3 groups extremely reduced the rectal temperature of feverish rabbits(P<0.01),decreased the levels of serum tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),and interleukin-6(IL-6)(P<0.05,P<0.01),reduced the levels of cyclic adenosine monophosphate(cAMP)and prostaglandin E2(PGE2)in the cerebrospinal fluid(P<0.05 or P<0.01),and downregulated the expression of NF-κB p65 protein in the hypothalamus.The experiment indicated that adding dewdrops from 3.6 g/kg and 7.2 g/kg DAF can alleviate the damage form heat stress.关键词
艳山姜纯露/兔/解热作用/啤酒酵母/内生致热原/NF-κB p65Key words
dewdrops from Aplinia zerubet fruits/rabbit/antipyretic effects/brewer's yeast/endogenous pyrogen/NF-κB p65分类
农业科技引用本文复制引用
伍春凤,吴焕,王冰冰,黄诗萍,韦凤超,吴冰燕,梁子宁,许立拔..艳山姜纯露对啤酒酵母致热家兔的解热作用及下丘脑NF-κB表达的影响[J].饲料研究,2024,47(22):73-77,5.基金项目
广西科技基地和人才专项(项目编号:桂科AD21238031) （项目编号:桂科AD21238031）
广西重点研发计划项目(项目编号:桂科AB21196016) （项目编号:桂科AB21196016）
广西壮瑶药重点实验室(项目编号:桂科基字[2014]32号) （项目编号:桂科基字[2014]32号）
壮瑶药协同创新中心(项目编号:桂教科研[2013]20号) （项目编号:桂教科研[2013]20号）
广西壮族自治区民族药资源与应用工程研究中心(项目编号:桂发改高技函[2020]2605号) （项目编号:桂发改高技函[2020]2605号）
国家自然科学基金项目(项目编号:82060695) （项目编号:82060695）
广西一流学科中药学(民族药学)(项目编号:桂教科研[2018]12号) （民族药学）
广西中医药大学科研项目(项目编号:05018028F2) （项目编号:05018028F2）
