摘要
Abstract
Objective To analyze the clinical features and risk factors of nosocomial infection in premature infants.Methods Clinical data of 2366 premature infants admitted to Department of Neonatology,Puning Maternal and Child Health Hospital from January 2013 to December 2023 were collected.Clinical characteristics of nosocomial infection in premature infants were summarized,and risk factors were analyzed.Results Among 2366 premature infants,73(3.09%)had nosocomial infection.Gestational age,length of hospital stay,birth weight,invasive procedure,duration of antibiotic use,parenteral nutrition support,and feeding intolerance(FI)were associated with nosocomial infection in premature infants(P<0.05).Gender,mode of delivery,premature rupture of membranes,placental abruption,placenta previa,amniotic fluid contamination,and twins were not associated with nosocomial infection in preterm infants(P>0.05).Multivariate analysis showed that gestational age 28-32 weeks(β=1.749,OR=5.747,95%CI=3.577-9.235),length of hospital stay>2 weeks(β=2.129,OR=8.408,95%CI=5.104-13.851),birth weight<1500 g(β=1.804,OR=6.072,95%CI=3.777-9.763),invasive procedures(β=2.221,OR=9.214,95%CI=5.705-14.884),duration of antibiotic use>7 days(β=0.876,OR=2.402,95%CI=1.505-3.835),parenteral nutrition support>7 days(β=2.094,OR=8.120,95%CI=4.431-14.879),and FI(β=1.062,OR=2.891,95%CI=1.809-4.621)were high risk factors for nosocomial infection in preterm infants(P<0.05).Conclusion Premature infants with small gestational age,long hospital stay,low birth weight,invasive procedures,long antibiotic use time are prone to nosocomial infections.Clinical intervention measures should be formulated according to the above factors to reduce the occurrence of nosocomial infections in premature infants.关键词
早产儿/喂养不耐受/医院感染/肠外营养支持Key words
Premature infant/Feeding intolerance/Nosocomial infection/Parenteral nutritional support分类
医药卫生
