妇儿健康导刊2024，Vol.3Issue(24)：195-199,5.DOI:10.3969/j.issn.2097-115X.2024.24.043
毛细血管渗漏指数联合补体C3对儿童脓毒症早期预后的预测价值
Predictive value of capillary leakage index combined with complement C3 in the early prognosis of sepsis in children
叶国静 1黄海忠 1张红 1邓国雄 1谢培林 1王静1
作者信息
- 1. 广东省惠州市第三人民医院儿科,广东惠州 516002
- 折叠
摘要
Abstract
Objective To explore the value of capillary leakage index(CLI)combined with complement C3 in predicting the early prognosis of sepsis in children.Methods A retrospective analysis was performed on 50 children with sepsis who were admitted to the Third People's Hospital of Huizhou City from December 2021 to October 2023 and divided into general sepsis group(n=32)and septic shock group(n=18)according to the severity of the disease.The CLI and complement C3 between the two groups were compared,and the relationship between CLI,complement C3 and sequential organ failure assessment(SOFA)score was analyzed.The influencing factors of early prognosis in children with sepsis were analyzed by univariate and multifactorial analysis,and the predictive role of CLI and complement C3 on poor prognosis in sepsis was analyzed using receiver operator characteristic(ROC)curve.Results The septic shock group had higher CLI and lower complement C3 than the general sepsis group(P<0.05).The complement C3 was negatively correlated with SOFA score(r=-0.52,P<0.001),while CLI was positively correlated with SOFA score(r=0.49,P<0.001).The incidence rate of poor prognosis in sepsis was 42.00%.Multifactorial logistic analysis showed that the CLI,SOFA,complement C3,and Th/Ts were independent predictors of poor prognosis in sepsis(P<0.05).ROC curve showed that the area under the curve of complement C3 combined with CLI for predicting poor prognosis was 0.874(95%CI:0.847-0.942),and the Youden index was 0.778.The combined predictive value was higher than that of each index alone(P<0.05).Conclusion There are significant increases in the levels of C3 and CLI in children with sepsis,which can be used as indicators for the prognosis evaluation of sepsis,and their combination has a higher predictive value.关键词
补体C3/毛细血管渗漏指数/脓毒症Key words
Complement C3/Capillary leakage index/Sepsis分类
医药卫生引用本文复制引用
叶国静,黄海忠,张红,邓国雄,谢培林,王静..毛细血管渗漏指数联合补体C3对儿童脓毒症早期预后的预测价值[J].妇儿健康导刊,2024,3(24):195-199,5.
