畜牧与兽医2025，Vol.57Issue(1)：138-146,9.
TRIM蛋白在宿主抗流感病毒感染中的作用
Role of TRIM protein in host defence against influenza infection
摘要
Abstract
Ubiquitination is one of the protein post-translational modifications(PTMs)found in all eukaryotes,regulating thousands of proteins.Among them,the ubiquitin-proteasome system(UPS)can induce the proteasome to degrade target proteins,and then activates a variety of signaling pathways,which plays a regulatory role in a variety of cell life cycles,and plays a crucial role in many aspects of cell life processes.Tripartite motif-containing proteins(TRIMs)are a class of E3 ubiquitin ligases that play an important role in the regulation of in-tracellular signal transduction,development,apoptosis,protein quality control,innate immune response,autophagy and cancer.In this re-view,we have focused on the role of TRIMs in anti-influenza virus infection,including the regulation of the innate immune response media-ted by the direct effect on influenza virus proteins,pathogen recognition receptor(PRR),and induction of viral autophagy.This provides more new ideas for the prevention and control of influenza virus,and further lays a theoretical foundation for in-depth research on the mecha-nism of anti-viral infection mediated by TRIM family members.关键词
流感病毒/泛素化/抗病毒免疫/TRIM家族Key words
influenza virus/ubiquitination/antiviral immunity/TRIM family分类
农业科技引用本文复制引用
胡欣妍,高明阳,杨宣叶,王进千,吴玉湖,马晓霞,张德荣..TRIM蛋白在宿主抗流感病毒感染中的作用[J].畜牧与兽医,2025,57(1):138-146,9.基金项目
中央高校基本科研业务费专项资金资助(31920230063) （31920230063）
