中风与神经疾病杂志2024，Vol.41Issue(12)：1102-1105,4.DOI:10.19845/j.cnki.zfysjjbzz.2024.0210
高原海马区神经发生与癫痫的研究进展
Research advances in hippocampal neurogenesis and epilepsy in high-altitude area
摘要
Abstract
Epilepsy is a clinical syndrome caused by highly synchronized abnormal discharges of brain neurons due to various causes.Studies have shown that abnormal hippocampal neurogenesis is observed in both human epilepsy patients and animal models of epilepsy,and abnormal neurogenesis can alter normal neural circuits in the hippocampus and promote the development of hippocampal sclerosis,ultimately leading to the development and progression of epilepsy.The low-pressure hypoxic environment unique to the plateau affects hippocampal neurogenesis by regulating hypoxia-inducible factors,the Wnt signaling pathway,the Notch signaling pathway,and EPO,thereby affecting the susceptibility to epilepsy and the development and progression of epilepsy.This article reviews the mechanism of interaction between hippocampal neurogenesis and epilepsy in high-altitude hypoxic environments,in order to provide potential strategies and targets for the treatment of epilepsy.关键词
神经发生/海马/癫痫/高海拔/缺氧诱导因子Key words
Neurogenesis/Hippocampus/Epilepsy/High altitude/Hypoxia-inducible factor分类
医药卫生引用本文复制引用
朱新远,樊青俐..高原海马区神经发生与癫痫的研究进展[J].中风与神经疾病杂志,2024,41(12):1102-1105,4.基金项目
青海省科技计划项目(2022-ZJ-761) （2022-ZJ-761）
