中风与神经疾病杂志2024，Vol.41Issue(12)：1142-1147,6.DOI:10.19845/j.cnki.zfysjjbzz.2024.0219
VEGF在脑出血中的调控机制及治疗作用
Regulatory role and therapeutic effects of VEGF in intracerebral hemorrhage
摘要
Abstract
In intracranial hemorrhage,the rupture of intracranial blood vessels results in elevated intracranial pres-sure and reduced cerebral blood flow and perfusion pressure,which directly impact blood oxygen supply to cause a series of brain injuries that are hard to recover.Angiogenesis has been demonstrated favorable for the prognosis of cerebral hem-orrhage.Vascular endothelial growth factor(VEGF)is regarded as a main regulator of angiogenesis and vasculogenesis,which can regulate the pathological mechanism of cerebral hemorrhage through multiple pathways.It can not only facilitate and mediate the formation of new blood vessels to enhance oxygen and nutrient supply in bleeding areas,but also protect neural cells through alleviating inflammation,inhibiting cell apoptosis,up-regulating trophic factors,and down-regulating toxic proteins.This review focuses on the regulatory role of VEGF in the pathological process of cerebral hemorrhage as well as its effects in the treatment of cerebral hemorrhage.关键词
脑出血/血管内皮再生因子/血管再生/神经保护/治疗Key words
Intracerebral hemorrhage/Vascular endothelial growth factor/Angiogenesis/Neuroprotection/Treatment分类
医药卫生引用本文复制引用
李晶怡,丛婧,霍宏,张莹,王东岩..VEGF在脑出血中的调控机制及治疗作用[J].中风与神经疾病杂志,2024,41(12):1142-1147,6.基金项目
国家自然科学基金面上项目(82374601) （82374601）
黑龙江中医药管理局青年中医药科研课题(ZHY2024-229) （ZHY2024-229）
黑龙江中医药大学创新团队建设项目(2017sit01) （2017sit01）
