中国普通外科杂志2024，Vol.33Issue(11)：1883-1889,7.DOI:10.7659/j.issn.1005-6947.2024.11.015
m6A甲基化修饰在甲状腺癌发生发展中的作用研究进展
Role of m6A methylation modification in the occurrence and development of thyroid cancer:a review of research progress
摘要
Abstract
Thyroid cancer (TC) is the most common endocrine malignancy. Although most patients have a favorable prognosis following standardized treatment,a subset experiences rapid disease progression and poor outcomes. Recent studies have identified N6-methyladenosine (m6A) methylation as the most prevalent RNA modification,which regulates RNA transcription,maturation,degradation,and stability,playing a role throughout the tumorigenesis process. Consequently,m6A methylation has been extensively studied in tumor treatment and prevention. Changes in m6A levels can lead to abnormal activation or inhibition of oncogenes or tumor suppressor genes in TC,thereby contributing to its initiation and progression. This review summarizes the concept of m6A methylation,the components and functions of its regulatory factors,its role in the development and progression of TC,and its implications for treatment and prognosis.关键词
甲状腺肿瘤/N6-甲基腺嘌呤/预后/综述Key words
Thyroid Neoplasms/N6-Methyladenosine/Prognosis/Review分类
医药卫生引用本文复制引用
田宏友,程璐,任艳,郭琎祎,马家骧,宋爱琳..m6A甲基化修饰在甲状腺癌发生发展中的作用研究进展[J].中国普通外科杂志,2024,33(11):1883-1889,7.基金项目
甘肃省自然科学基金资助项目(20JR5RA342,21JR11RA109) （20JR5RA342,21JR11RA109）
甘肃省兰州市城关区科技计划基金资助项目(2022SHFZ0010). （2022SHFZ0010）
