中国兽医杂志2025，Vol.61Issue(1)：1-6,6.DOI:10.20157/j.cnki.zgsyzz.2025.01.001
犬髓外浆细胞瘤的组织病理学诊断和免疫组织化学分析
Histopathological Diagnosis and Immunohistochemical Analysis of Canine Extramedullary Plasmacytoma
摘要
Abstract
Extramedullary plasmacytoma(EMP)is a relatively rare tumor in dogs.To investigate the histopathological and immunohistochemical characteristics of canine EMP,this study analyzed skin tumor samples from affected dogs using hematoxylin-eosin(H.E.)staining and Congo red staining for histopathological diagnosis.Immunohistochemical(IHC)staining was further performed to examine the expression of EMP-specific markers,including paired box gene 5(PAX5),cluster of differentiation 20(CD20),cluster of differentiation 79a(CD79a),multiple myeloma oncogene 1(MUM1),and canine immunoglobulin G(Canine IgG).The results showed that the tumors in both cases lacked encapsulation but were well-demarcated from surrounding tissues.Tumor cells exhibited plasmacytoid or plasmablastic characteristics,and amyloid deposition was observed in the tumor tissue of Case 2.Immunohistochemically,the tumor cells in Case 1 were negative for PAX5,CD20,and MUM1,but positive for CD79a and Canine IgG.In Case 2,the tumor cells were negative for PAX5,but positive for CD20,CD79a,MUM1,and Canine IgG.These findings confirmed that both cases were cutaneous forms of canine EMP based on histopathological and IHC results.This study provides significant pathological evidence for the accurate diagnosis of canine EMP,serving as an important reference for clinical and research purposes.关键词
犬/髓外浆细胞瘤(EMP)/组织病理学/免疫组织化学/鉴别诊断Key words
canine/extramedullary plasmacytoma(EMP)/histopathology/immunohistochemistry/differential diagnosis分类
畜牧业引用本文复制引用
张竞,李伊萌,石俊超,马莹,贺文琦,陆慧君..犬髓外浆细胞瘤的组织病理学诊断和免疫组织化学分析[J].中国兽医杂志,2025,61(1):1-6,6.基金项目
吉林大学专业学位研究生课程案例库建设项目(2024ALK055) （2024ALK055）
吉林大学本科教学改革研究项目(2023XYB173,2023XZD117) （2023XYB173,2023XZD117）
