中国兽医杂志2025，Vol.61Issue(1)：14-18,5.DOI:10.20157/j.cnki.zgsyzz.2025.01.003
犬卵巢颗粒细胞瘤的诊断和治疗
Diagnosis and Treatment of Canine Ovarian Granulosa Cell Tumor
摘要
Abstract
Ovarian granulosa cell tumors in dogs are relatively rare in China.This report presents a case of a dog referred for cough and dyspnea.Laboratory and imaging examinations confirmed an ovarian tumor associated with right middle lobe consolidation,pleural effusion,and peritoneal effusion.The tumor was surgically removed,and further histopathological examination was performed.Hematoxylin-eosin(H.E.)staining revealed loss of ovarian tissue architecture,with tumor cells showing a variety of morphologies,including solid sheets,cords,trabecular,or nest-like arrangements.The cytoplasm was abundant,and the nuclei appeared vacuolated,with rare mitosis.Nucleoli were visible,and chromatin was coarse.Immunohistochemical staining results showed that the specific marker inhibin-α(INH-α)was 5%positive for ovarian granulosa cell tumors,while non-specific markers wilms tumor 1(WT1)and cluster of differentiation 10(CD10)were positive.The dog was diagnosed with an ovarian granulosa cell tumor and staged as malignant.The dog had a good recovery after surgery and was in stable condition at the 3-year follow-up with no recurrence,though continued observation was recommended.This report aims to summarize the diagnostic and treatment processes for ovarian granulosa cell tumors in dogs,providing valuable reference for clinical practice.关键词
犬/腹腔肿瘤/卵巢颗粒细胞瘤/免疫组织化学Key words
dog/abdominal tumor/ovarian granulosa cell tumor/immunohistochemistry分类
畜牧业引用本文复制引用
叶蒂,王鹿敏,李琦,张华,师福山,林琳,王华南..犬卵巢颗粒细胞瘤的诊断和治疗[J].中国兽医杂志,2025,61(1):14-18,5.基金项目
中央高校基本科研业务费专项资金(2022-KYY-517101-0005) （2022-KYY-517101-0005）
杭州城西科创大走廊创新发展专项资助(B231220.0005-46) （B231220.0005-46）
