中国兽医杂志2025，Vol.61Issue(1)：38-47,10.DOI:10.20157/j.cnki.zgsyzz.2025.01.007
2016-2023年上海市浦东新区和松江区畜禽源大肠埃希菌耐药性比较
Comparison of Drug Resistance of Escherichia coli Isolated from Livestock and Poultry in Pudong New Area and Songjiang District of Shanghai from 2016 to 2023
摘要
Abstract
To investigate the trends in drug resistance of Escherichia coli(E.coli)from livestock and poultry in Pudong New Area and Songjiang Districts of Shanghai(hereafter referred to as the"two districts")from 2016 to 2023,this study collected 401 and 490 anal swab samples from livestock and poultry farms in the two districts,respectively.E.coli isolates were identified,and the antimicrobial usage on these farms was surveyed.The drug susceptibility of the isolated E.coli strains against 14 antimicrobial agents across 10 classes was determined using the broth microdilution method.The results showed that antimicrobial usage varied across farms in the two districts.A total of 333 and 350 E.coli isolates were obtained from the two districts,with isolation rates of 83.04%and 71.43%,respectively.High resistance rates were observed for tetracycline(87.09%,82.00%),sulfisoxazole(77.78%,82.00%),ampicillin(82.58%,70.30%),and trimethoprim/sulfamethoxazole(70.87%,76.90%).Low resistance rates were found for ceftazidime(6.61%,6.90%)and colistin(0.90%,0.90%),and no resistance to meropenem was detected.Multidrug-resistant strains accounted for 87.99%and 81.71%of isolates,respectively.Over the eight years,the overall resistance rates,proportion of multidrug-resistant strains,and resistance spectrum breadth showed a declining trend,with a more significant reduction in Songjiang District.These findings indicate that E.coli from livestock and poultry in Pudong New Area and Songjiang Districts exhibit high resistance rates to certain antimicrobials and severe multidrug-resistant issues.However,under the framework of antimicrobial reduction policies,the drug resistance levels have shown improvement,with Songjiang District experiencing a more substantial decrease.关键词
大肠埃希菌/耐药性/兽用抗菌药/减量化行动/浦东新区/松江区Key words
Escherichia coli/drug resistance/veterinary antimicrobial drugs/reduction action/Pudong New Area/Songji-ang District分类
畜牧业引用本文复制引用
方雅红,张妤,孙冰清,姜芹,龚志亮,李闽,商军,张亦菲..2016-2023年上海市浦东新区和松江区畜禽源大肠埃希菌耐药性比较[J].中国兽医杂志,2025,61(1):38-47,10.基金项目
上海市科技兴农项目(2022-02-08-00-12-F01100) （2022-02-08-00-12-F01100）
