摘要
Abstract
Objective:To investigate the application effect of ultrasound-guided transverse abdominal muscle plane(TAP)block combined with Hydromorphone in elderly patients undergoing laparoscopic radical resection of colon cancer.Method:A total of 120 elderly patients undergoing laparoscopic radical resection of colon cancer treated in Beijing Changping District Hospital from January 2021 to December 2023 were selected as the study objects.According to the random number table method,they were divided into reference group and experimental group,with 60 cases in each group.Both groups were given general anesthesia,the reference group was given Hydromorphone analgesic pump,and the experimental group was given ultrasound-guided TAP block based on the reference group.Pain degree at 1 h,12 h and 24 h after surgery,stress index before surgery,1 h and 24 h after surgery,heart rate(HR)and mean arterial pressure(MAP)before surgery,1 h and 48 h after surgery,and adverse reactions were compared between the two groups.Result:At 12 h and 24 h after surgery,VAS scores of both groups were lower than those of 1 h after surgery,and VAS scores of the experimental group were lower than those of the reference group,the differences were statistically significant(P＜0.05).The levels of norepinephrine(NE)and cortisol(Cor)in the two groups 1 h and 24 h after surgery were higher than those before surgery,at 24 h after surgery,the levels of NE and Cor in both groups were lower than those in 1 h after surgery,and the levels of NE and Cor in the experimental group were lower than those in the reference group,the differences were statistically significant(P＜0.05).At 1 h and 48 h after surgery,HR and MAP levels in both groups were significantly higher than those before surgery,at 48 h after surgery,HR and MAP levels in both groups were lower than those in 1 h after surgery,and MAP and HR levels in the experimental group were lower than those in the reference group,the differences were statistically significant(P＜0.05).The incidence of adverse reactions was compared between the two groups(P＞0.05).Conclusion:Ultrasound-guided TAP block plus Hydromorphone can promote postoperative pain relief,reduce postoperative stress response,stabilize hemodynamics,and have good safety in elderly patients undergoing laparoscopic radical colon cancer surgery.关键词
腹腔镜结肠癌根治术/老年/超声/腹横肌平面阻滞/氢吗啡酮/应激指标Key words
Laparoscopic radical resection of colon cancer/Elderly/Ultrasound/Transversal plane block/Hydromorphone/Stress response
