经皮椎体成形术联合唑来膦酸治疗老年骨质疏松性椎体压缩性骨折的效果OA
Application Effect of Percutaneous Vertebroplasty Combined with Zoledronic Acid in the Treatment of Osteoporotic Vertebral Compression Fractures in the Elderly
目的:探讨经皮椎体成形术联合唑来膦酸治疗老年骨质疏松性椎体压缩性骨折的效果.方法:选择 2020 年4 月—2023 年 3 月岷县中医医院中医骨伤科收治的行经皮椎体成形术治疗的 100 例老年骨质疏松性椎体压缩性骨折患者,以随机数表法将其分为观察组 50 例和比较组 50 例,比较组患者实施手术治疗后配合常规药物治疗,观察组则联合唑来膦酸治疗,比较两组患者临床治疗效果、骨折愈合时间,治疗前后腰椎骨密度、右股骨密度、视觉模拟评分法(visual analogue scale,VAS)评分、日常生活能力量表(activity of daily living scale,ADL)评分和功能障碍指数(Oswestry dysfunction index,ODI)及骨水泥渗漏、脊髓神经损伤、肺栓塞等并发症的情况.结果:治疗后,观察组患者总有效率、腰椎骨密度、右股骨密度、ADL评分高于比较组,骨折愈合时间早于比较组,VAS评分、ODI低于比较组,差异有统计学意义(P＜0.05).观察组并发症发生率略高于比较组,差异无统计学意义(P＞0.05).结论:经皮椎体成形术联合唑来膦酸疗效好,可增强老年骨质疏松性椎体压缩性骨折患者的骨密度,减轻疼痛感和功能障碍,提高日常生活能力,缩短骨折愈合时间,安全可靠.
Objective:To explore the application effect of percutaneous vertebroplasty combined with Zoledronic Acid in the treatment of elderly osteoporotic vertebral compression fractures.Method:A total of 100 elderly patients with osteoporotic vertebral compression fractures treated with percutaneous vertebroplasty in the Department of Traditional Chinese Medicine Orthopedics and Traumatology of Min County Traditional Chinese Medicine Hospital from April 2020 to March 2023 were selected.They were randomly divided into observation group of 50 cases and comparison group of 50 cases by random number table method.The comparison group received surgical treatment combined with conventional drug treatment,while the observation group received treatment of combined with Zoledronic Acid.The clinical treatment effects,fracture healing time,and lumbar spine bone density,right femur and tibia bone density,the visual analogue scale(VAS)score,activity of daily living scale(ADL),Oswestry dysfunction index(ODI)before and after treatment,as well as the incidence of complications such as bone cement leakage,spinal cord nerve injury,and cardiopulmonary embolism were compared between the two groups.Result:After treatment,the total effective rate,lumbar spine bone density,right femur and tibia bone density,and ADL score of the observation group were higher than those of the comparison group,the fracture healing time was earlier than that of the comparison group,VAS pain score,and ODI were lower than those of the comparison group,and the differences were statistically significant(P＜0.05).The incidence of complications was higher in the observation group than that in the comparison group,but the difference was not statistically significant(P＞0.05).Conclusion:Percutaneous vertebroplasty combined with Zoledronic Acid has a guaranteed therapeutic effect of elderly patients with osteoporotic vertebral compression fractures,it enhances bone density,reduces pain and functional impairment,improves the daily living ability,shortens fracture healing time,and is safe and reliable.
马立峰;董万涛;路超;邱海峰;苏卫军;陈正卫;李永红;王栋;安蓬田;何小宁
岷县中医院 甘肃 岷县 748400
功能障碍指数老年骨质疏松性椎体压缩性骨折唑来膦酸经皮椎体成形术日常生活能力
Oswestry dysfunction indexElderlyOsteoporotic vertebral compression fracturesZoledronic AcidPercutaneous vertebroplastyDaily living ability
《中外医学研究》 2024 (035)
19-23 / 5
定西市科技计划项目(DX2022BR13)
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