哌拉西林钠他唑巴坦联合雾化对慢性阻塞性肺疾病急性加重期患者疗效的影响OA
Influence of Piperacillin Sodium and Tazobactam Combined with Atomization on Curative Effect of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
目的:探讨哌拉西林钠他唑巴坦联合雾化对慢性阻塞性肺疾病急性加重期(AECOPD)患者疗效的影响.方法:选取 2018 年 11 月—2023 年 11 月于盐城市第三人民医院确诊的 80 例AECOPD患者作为研究对象,采用简单随机分组将患者分为联合组(n=40)和常规组(n=40).常规组采用哌拉西林钠他唑巴坦治疗,联合组采用哌拉西林钠他唑巴坦联合雾化治疗,两组均持续治疗 2 周.比较两组临床疗效、肺功能[用力肺活量(FVC)、第 1 秒用力呼气容积(FEV1)和FEV1/FVC]、外周血指标[中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)]、血气指标[血氧饱和度(SaO2)、二氧化碳分压(PaCO2)及氧分压(PaO2)]及治疗期间不良反应.结果:联合组总有效率为 92.50%,明显高于常规组的 75.00%,差异有统计学意义(P＜0.05);治疗后,两组FVC、FEV1、FEV1/FVC、SaO2、PaO2 较治疗前升高,且联合组高于常规组,差异有统计学意义(P＜0.05);治疗后,两组NLR、PLR、PaCO2 较治疗前降低,且联合组低于常规组,差异有统计学意义(P＜0.05);联合组治疗期间不良反应总发生率为 7.50%,与常规组的 12.50%比较,差异无统计学意义(P＞0.05).结论:哌拉西林钠他唑巴坦联合雾化治疗可以明显提高AECOPD患者的效果,改善肺功能,降低NLR、PLR水平,维持血气平衡.
Objective:To explore the influence of Piperacillin Sodium and Tazobactam combined with atomization on curative effect of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Method:A total of 80 patients with AECOPD who diagnosed in Yancheng Third People's Hospital from November 2018 to November 2023 were selected as the research objects,the patients were divided into the combined group(n=40)and the conventional group(n=40)by simple random grouping.The conventional group was treated with Piperacillin Sodium and Tazobactam,and the combined group was treated with Piperacillin Sodium and Tazobactam combined with atomization,two groups were treated for 2 weeks.The clinical efficacy,lung function[forced vital capacity(FVC),forced expiratory volume in one second(FEV1)and FEV1/FVC],peripheral blood indexes[neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR)],blood gas indexes[blood oxygen saturation(SaO2),partial pressure of carbon dioxide(PaCO2)and partial pressure of oxygen(PaO2)]and adverse reactions during treatment were compared between two groups.Result:The total effective rate of the combined group was 92.50%,which was significantly higher than 75.00%of the conventional group,and the difference was statistically significant(P＜0.05);after treatment,the FVC,FEV1,FEV1/FVC,SaO2 and PaO2 in two groups were higher than those before treatment,and those in the combined group were higher than the conventional group,the differences were statistically significant(P＜0.05);after treatment,the NLR,PLR and PaCO2 in two groups were lower than those before treatment,and those in the combined group were lower than the conventional group,the differences were statistically significant(P＜0.05);the total incidence of adverse reactions during treatment in the combined group was 7.50%,compared with 12.50%in the conventional group,the difference was not statistically significant(P＞0.05).Conclusion:Piperacillin Sodium and Tazobactam combined with atomization can significantly improve the effect of AECOPD patients,improve lung function,reduce NLR and PLR levels,and maintain blood gas balance.
陈建华;沈爱华;顾龙强
盐城市第三人民医院 江苏 盐城 224001
慢性阻塞性肺疾病急性加重期哌拉西林钠他唑巴坦雾化肺功能
Acute exacerbation of chronic obstructive pulmonary diseasePiperacillin Sodium and TazobactamAtomizationPulmonary function
《中外医学研究》 2024 (035)
23-26 / 4
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