摘要
Abstract
Objective:To explore the effects of Yiqi Anshen Decoction combined with conventional chemotherapy on the efficacy,immunity and human epidermal growth factor receptor 2(Her-2),topoisomerase Ⅱ(TOPⅡ)in the treatment of breast cancer patients with Qi and blood deficiency.Method:Eighty-four cases of breast cancer patients with Qi and blood deficiency type admitted to Panzhihua Integrated Traditional Chinese and Western Medicine Hospital from January 2020 to January 2022 were selected as the study subjects,and they were divided into two groups by random number table method.The 42 patients in the control group were treated with conventional chemotherapy regimen,and the 42 cases in the observation group were treated with Yiqi Anshen Decoction combined with conventional chemotherapy regimen.The clinical efficacy of the two groups,immune function,Her-2,TOPⅡ positive expression before and after treatment and the incidence of adverse reactions were compared.Result:The tumor control rate in the observation group was 78.57%,which was higher than 57.14%in the control group,the difference was statistically significant(P＜0.05).After treatment,the levels of CD4+,CD4+/CD8+in both groups were increased,the CD8+decreased,and the levels of CD4+,CD4+/CD8+in the observation group were higher than those in the control group,and the level of CD8+was lower than that in the control group,the differences were statistically significant(P＜0.05).After treatment,the positive expression rates of Her-2 and TOPⅡ in both groups were lower than those of before treatment,and Her-2 and TOPⅡ in the observation group were 23.81%and 21.43%,respectively,which were lower than 45.24%and 42.86%in the control group,the differences were statistically significant(P＜0.05).The incidence of adverse reactions in the observation group was 9.52%,which was lower than 26.19%in the control group,the difference was statistically significant(P＜0.05).Conclusion:Yiqi Anshen Decoction combined with conventional chemotherapy has a significant effect on breast cancer patients with Qi and blood deficiency type,which can effectively improve the immune function of patients,reduce the positive expression of Her-2 and TOPⅡ,with less adverse reactions and good safety.关键词
乳腺癌/气血两虚型/益气安神汤/化疗/免疫功能/人表皮生长因子受体2/拓扑异构酶ⅡKey words
Breast cancer/Qi and blood deficiency type/Yiqi Anshen Decoction/Chemotherapy/Immunity/Human epidermal growth factor receptor 2/Topoisomerase Ⅱ
