摘要
Abstract
Objective:To investigate the clinical effect of high-throughput hemodialysis in the treatment of hyperphosphatemia in chronic kidney disease and its impact on cognitive dysfunction.Method:A total of 80 patients with hyperphosphatemia in chronic kidney disease who admitted to Guangze County Hospital from February 2020 to December 2022 were selected as the research objects,the patients were divided into control group and observation group according to the random number table method,with 40 cases in each group.The control group was treated with basic treatment of hyperphosphatemia and conventional hemodialysis,while the observation group was treated with basic treatment of hyperphosphatemia and high-throughput hemodialysis.The cognitive function,renal function,blood phosphorus,blood calcium,blood parathyroid hormone,inflammatory factors and cardiovascular and cerebrovascular events were compared between two groups.Result:The Montreal cognitive assessment(MoCA)score and serum calcium level in the observation group after treatment were higher than those in the control group,and the incidence of cognitive dysfunction,blood urea nitrogen(BUN),serum creatinine(Scr),β2-microglobulin(β2-MG),blood phosphorus,blood parathyroid hormone,C-reactive protein(CRP)and procalcitonin(PCT)levels were lower than those in the control group,and the differences were statistically significant(P＜0.05);there was no significant difference in the incidence of cardiovascular and cerebrovascular events between two groups(P＞0.05).Conclusion:The application of high-throughput hemodialysis in the clinical treatment of patients with hyperphosphatemia in chronic kidney disease can improve cognitive function,renal function,regulate body's blood calcium and blood phosphorus content,improve body's inflammatory state,and does not increase cardiovascular and cerebrovascular events.关键词
慢性肾脏病高磷血症/高通量血液透析/认知功能障碍/肾功能/血磷/血钙Key words
Hyperphosphatemia in chronic kidney disease/High-throughput hemodialysis/Cognitive dysfunction/Renal function/Blood phosphorus/Blood calcium
