血清PCT、CRP与HMGB1对重症肺炎合并呼吸衰竭患者的预后预测价值OA

Objective:To investigate the prognosticative value of serum procalcitonin(PCT),C-reactive protein(CRP)and high mobility group protein B1(HMGB1)in patients with severe pneumonia complicated with respiratory failure.Method:116 patients with severe pneumonia complicated with respiratory failure admitted to Second Affiliated Hospital of Xiamen Medical College from January 2019 to December 2023 were selected as the study objects.Serum PCT,CRP and HMGB1 levels were detected in all patients,and the patients were divided into good prognosis group(n=80)and poor prognosis group(n=36)according to the prognosis 28 days after admission.To analyse the relevant factors affecting patients'prognosis and the predictive value of serum PCT,CRP and HMGB1.Result:The oxygenation index of the poor prognosis group was lower than that of the good prognosis group,and the APACHE Ⅱ score,serum PCT,CRP and HMGB1 levels were higher than those of the good prognosis group,and the difference is statistically significant(P<0.05).Analysis showed that APACHE Ⅱ score(OR=3.789),serum PCT(OR=5.259),CRP(OR=5.936)and HMGB1(OR=5.181)were risk factors affecting the prognosis of patients with severe pneumonia complicated with respiratory failure.ROC curve analysis showed that the combined detection of serum PCT,CRP and HMGB1 predicted the prognosis of patients with severe pneumonia complicated with respiratory failure with an AUC of 0.970,a sensitivity of 91.7%and a specificity of 93.7%,which were higher than the detection of each single index.Conclusion:Serum PCT,CRP and HMGB1 can predict the prognosis of patients with severe pneumonia complicated with respiratory failure,and the combined application is more effective.