急性心力衰竭患者血钾、MMP-9、FT3/FT4比值变化及其与预后的关系OA
Changes in Blood Potassium,MMP-9,FT3/FT4 Ratio and Their Relationship with Prognosis in Patients with Acute Heart Failure
目的:探究急性心力衰竭(AHF)患者血钾、基质金属蛋白酶-9(MMP-9)、游离三碘甲状腺原氨酸/游离甲状腺素(FT3/FT4)比值变化及其与预后的关系.方法:选取 2021 年 8 月—2023 年 8 月宜都市人民医院收治的 118 例AHF患者作为AHF组,选取同期体检的 56 名健康成年人为对照组.比较两组血钾、MMP-9、FT3/FT4 比值,并分析各指标与AHF疾病严重程度的相关性.所有AHF患者均随访 1 年,分析血钾、MMP-9、FT3/FT4 比值对患者预后的预测价值.结果:AHF组血清钾、FT3、FT4 水平低于对照组,FT3/FT4 比值小于对照组,MMP-9 水平高于对照组,差异有统计学意义(P<0.05).纽约心脏病协会(NYHA)心功能分级Ⅳ级患者血清钾、FT3 水平低于Ⅰ～Ⅱ级、Ⅲ级患者,FT3/FT4 比值小于Ⅰ～Ⅱ级、Ⅲ级患者,MMP-9 水平高于Ⅰ～Ⅱ级、Ⅲ级患者,差异有统计学意义(P<0.05).AHF患者血钾水平、FT3/FT4 比值与NYHA心功能分级呈负相关,MMP-9 水平与NYHA心功能分级呈正相关(r=-0.649、-0.525、0.673,P<0.05).预后不良患者血清钾、FT3、FT4 水平低于预后较好患者,FT3/FT4 比值小于预后较好患者,MMP-9 水平高于预后较好患者,差异有统计学意义(P<0.05).各指标联合检测预测AHF患者预后的AUC值大于MMP-9、FT3/FT4 比值单独检测,差异有统计学意义(P<0.05).结论:AHF患者血钾、MMP-9、FT3/FT4 比值变化与病情严重程度相关,且各指标联合检测对患者预后具有预测价值.
Objective:To investigate the changes in blood potassium,matrix metalloproteinase-9(MMP-9),and free triiodothyronine/free thyroxine(FT3/FT4)ratio in patients with acute heart failure(AHF)and their relationship with prognosis.Method:118 AHF patients admitted to Yidu People's Hospital from August 2021 to August 2023 were selected as the AHF group,and 56 healthy adults who underwent physical examinations during the same period were used as controls.The blood potassium,MMP-9 and FT3/FT4 ratio were compared,and the correlation between each indicator and the severity of AHF disease were analyzed.All AHF patients were followed up for 1 year to analyze the predictive value of blood potassium,MMP-9,and FT3/FT4 ratio on patient prognosis.Result:The serum potassium,FT3,and FT4 levels in the AHF group were lower than those in the control group,the FT3/FT4 ratio in the AHF group was lower than that in the control group,and the MMP-9 level in the AHF group was higher than that in the control group(P<0.05).The serum potassium and FT3 levels of New York Heart Association(NYHA)grade Ⅳ patients were lower than those of grade Ⅰ-Ⅱ and Ⅲ patients,and grade Ⅲ patients were lower than those of grade Ⅰ-Ⅱ patients(P<0.05).The FT3/FT4 ratio of NYHA grade Ⅳ patients was lower than that of grade Ⅰ-Ⅱ and Ⅲ patients,and grade Ⅲ patients were lower than those of grade Ⅰ-Ⅱ patients(P<0.05).The MMP-9 levels in NYHA grade Ⅳ patients were higher than those in grade Ⅰ-Ⅱ and Ⅲ patients,and grade Ⅲ patients were higher than those in grade Ⅰ-Ⅱ patients(P<0.05).The blood potassium level and FT3/FT4 ratio of AHF patients are negatively correlated with NYHA cardiac function grading,while MMP-9 level is positively correlated with NYHA cardiac function grading(r=-0.649,-0.525,0.673,P<0.05).The serum potassium,FT3,and FT4 levels in the poor prognosis group were lower than those in the good prognosis group.The FT3/FT4 ratio was lower than that in the good prognosis group,and the MMP-9 levels were higher than those in the good prognosis group(P<0.05).The combined detection of various indicators predicted the AUC value of AHF patients,which was higher than MMP-9 and the FT3/FT4 ratio detected separately(P<0.05).Conclusion:The changes in blood potassium,MMP-9,and FT3/FT4 ratio in AHF patients are correlated with the severity of the disease,and the combined detection of various indicators has predictive value for patient prognosis.
邓世磊;彭芝斌;杨泽敏;李波华;皮晓波;杜艳
宜都市人民医院 湖北 宜都 443300
急性心力衰竭血钾基质金属蛋白酶-9游离三碘甲状腺原氨酸游离甲状腺素
Acute heart failureBlood potassiumMatrix metalloproteinase-9Free triiodothyronineFree thyroxine
《中外医学研究》 2024 (036)
13-16 / 4
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