中外医学研究2024，Vol.22Issue(36)：43-46,4.DOI:10.14033/j.cnki.cfmr.2024.36.012
阿利西尤单抗联合重组人脑利钠肽治疗急性ST段抬高型心肌梗死合并心力衰竭的临床观察
Clinical Observation of Aliciumab Combined with Recombinant Human Brain Natriuretic Peptide in the Treatment of Acute ST Segment Elevation Myocardial Infarction with Heart Failure
摘要
Abstract
Objective:Exploring the clinical efficacy of combination therapy with alloxiumab and recombinant human brain natriuretic peptide(rhBNP)in the treatment of acute ST segment elevation myocardial infarction(STEMI)with heart failure(HF).Method:92 patients with STEMI combined with HF,admitted to the Second Affiliated Hospital of Guangdong Medical University from January 2021 to April 2023,were selected as the study objects and randomly divided into a control group(n=46)and an observation group(n=46)according to random number table method.On the basis of conventional treatment,the control group received rhBNP treatment,while the observation group received a combination of alexiumab and rhBNP treatment.Patients of the two groups were followed up for 6 months,and the efficacy and incidence of major adverse cardiovascular events(MACE)were compared between the two groups.The cardiac function indicators[left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD)]and blood lipid indicators before and after treatment were compared between the two groups.Result:Compared with the control group,the observation group had a higher overall effective rate and a lower incidence of MACE,with a statistically significant difference(P<0.05).After treatment,LVEF increased in both groups,while LVEDD,LVESD values,and blood lipid indicators decreased.The observation group showed more significant improvement,and the difference was statistically significant(P<0.05).Conclusion:The combination of Aliciumab and rhBNP in the treatment of STEMI with HF can improve efficacy,improve blood lipid indicators,enhance heart function,and reduce the incidence of MACE.关键词
急性ST段抬高型心肌梗死/心力衰竭/重组人脑利钠肽/阿利西尤单抗/心功能Key words
Acute ST segment elevation myocardial infarction/Heart failure/Recombinant human brain natriuretic peptide/Alizumab/Cardiac function引用本文复制引用
郭英杰,许锦荣,陈晓欣,刘左玲..阿利西尤单抗联合重组人脑利钠肽治疗急性ST段抬高型心肌梗死合并心力衰竭的临床观察[J].中外医学研究,2024,22(36):43-46,4.基金项目
湛江市科技计划项目(2022A01136) （2022A01136）
