保健医学研究与实践2024，Vol.21Issue(9)：11-16,37,7.DOI:10.11986/j.issn.1673-873X.2024.09.02
生长抑素联合丙氨酰-谷氨酰胺治疗老年重症肺炎的临床疗效及对DAO、CRP及ACTH的影响
Somatostatin combined with alanyl-glutamine in the treatment of severe pneumonia in the elderly:clinical efficacy and impact on DAO,CRP,and ACTH
摘要
Abstract
Objective To explore the clinical efficacy of somatostatin combined with alanyl-glutamine in the treatment of se-vere pneumonia in the elderly and its impact on the levels of diamine oxidase(DAO),C-reactive protein(CRP),and adreno-corticotropic hormone(ACTH),aiming to provide a reference for the treatment of elderly patients with severe pneumonia.Methods A total of 102 elderly patients with severe pneumonia admitted to Suining Municipal Hospital of TCM from March 2020 to March 2022 were selected and allocated to a control group(n=48)and a study group(n=54)based on the treat-ment plan.The control group was treated with alanyl-glutamine in addition to symptomatic treatment,while the study group was treated with somatostatin in addition to the control group's treatment.The clinical efficacy,intestinal function,inflammatory stress status,pulmonary surfactant protein-A(SP-A),pulmonary surfactant protein-D(SP-D)levels,and adverse reaction occurrence were compared between the two groups.Results The overall response rate of treatment in the study group was significantly higher than that in the control group[90.74％(49/54)vs.72.92％(35/48);x2=5.555,P=0.018].Before treatment,no significant differences were noted in the urinary lactulose/mannitol(L/M)ratio,serum DAO,D-lactate,and bacterial endotoxin(BE)levels between the two groups(P＞0.05);after treatment,these levels were all decreased,and the study group had lower levels than the control group,with significant differences(P＜0.05).Before treatment,no significant differences were noted in the serum CRP,interleukin-6(IL-6),ACTH,and cortisol(COR)levels between the two groups(P＞0.05);after treatment,these levels were all decreased,and the study group had lower levels than the control group,with significant differences(P＜0.05).Before treatment,no significant differences were observed in the serum SP-A and SP-D levels between the two groups(P＞0.05);after treatment,these levels all showed an increase,and the study group had higher levels than the control group,with significant differences(P＜0.05).There was no statisti-cally significant difference in the incidence of adverse reactions between the two groups(x2=0.018,P=0.893).Conclusion The combination of somatostatin and alanyl-glutamine in the treatment of elderly patients with severe pneumonia has an ideal clinical efficacy,helps protect intestinal function,effectively reduces systemic inflammatory responses,improves pulmonary function,and does not increase the risk of adverse reactions,providing a more comprehensive and effective reference for the comprehensive treatment of elderly patients with severe pneumonia.关键词
生长抑素/丙氨酰-谷氨酰胺/重症肺炎/临床疗效/肠道功能/炎性应激Key words
Somatostatin/Alanyl-glutamine/Severe pneumonia/Clinical efficacy/Intestinal function/Inflammatory stress分类
医药卫生引用本文复制引用
李丹,李永新,卢小丽,柴贞,朱静,翁毅,朱光辉..生长抑素联合丙氨酰-谷氨酰胺治疗老年重症肺炎的临床疗效及对DAO、CRP及ACTH的影响[J].保健医学研究与实践,2024,21(9):11-16,37,7.基金项目
四川省中医药管理局科学技术专项课题(2021MS129). （2021MS129）
