儿科药学杂志2025，Vol.31Issue(1)：1-6,6.DOI:10.13407/j.cnki.jpp.1672-108X.2025.01.001
基于属性层次模型的儿童氟康唑药物利用评价
Drug Use Evaluation of Fluconazole Injection in Children Based on Attribute Hierarchy Model
周宬玥 1赵雯 2宋佳伟 3王卓芸 1姚奇 1张晨宇 1蔡和平1
作者信息
- 1. 安徽省儿童医院,合肥 230022
- 2. 合肥经济技术开发区海恒社区卫生服务中心,合肥 230051
- 3. 安徽省亳州市人民医院,安徽亳州 236800
- 折叠
摘要
Abstract
Objective:To establish the drug use evaluation(DUE)criteria for fluconazole in children,and perform the comprehensive evaluation on rationality of clinical practice of fluconazole,so as to provide basis for clinical rational drug use.Methods:DUE criteria for fluconazole in children was formulated according to drug instructions,relevant guidelines and expert consensus of fluconazole.Retrospective analysis was performed based on the DUE criteria for fluconazole in children,combined with multi-disease risk assessment(MDRA)program established by the West Virginia University School of Medicine,the attribute hierarchy model(AHM)was used to analyze and evaluate the rationality of 164 discharged children treated with fluconazole from Jan.to Jun.2023 in Anhui Children's Hospital.Results:Based on the established DUE criteria,the main problems related to the irrational clinical application of fluconazole included off-label indications,inappropriate usage and dosage,and no efficacy monitoring after administration.There were 63 cases(38.41％)with AHM scores(MRS)≥90,62 cases(37.80％)with 80≤MRS＜90,36 cases(21.95％)with 60≤MRS＜80,and 3 cases(1.83％)with MRS＜60.Conclusion:There are some irrational problems in the clinical application of fluconazole in our hospital,it is necessary to strengthen the management and supervision to promote rational drug use in children.The DUE criteria for fluconazole in children based on AHM model is simple and practical,and the evaluation results are systematic and intuitive.关键词
氟康唑/药物利用评价/属性层次模型/合理用药Key words
fluconazole/drug use evaluation/attribute hierarchy model/rational drug use分类
医药卫生引用本文复制引用
周宬玥,赵雯,宋佳伟,王卓芸,姚奇,张晨宇,蔡和平..基于属性层次模型的儿童氟康唑药物利用评价[J].儿科药学杂志,2025,31(1):1-6,6.
