Abstract
Objective:Based on the R language,to explore the traditional Chinese medicine syndrome types and elements and medication rules of tic disorder(TD)complicated with attention deficit hyperactivity disorder(ADHD)in children.Methods:CNKI,Wanfang,VIP,CBM,PubMed,the Cochrane Library,EMBase,and Web of Science were retrieved to collect literature related to traditional Chinese medicine in the treatment of TD complicated with ADHD from the establishment of the database to Nov.10th,2023.Literature were screened by Excel software,and the databases were established after the syndrome types and elements and traditional Chinese medicine were standardized.By using R language and RStudio software,the corresponding data mining,including association analysis and cluster analysis,was carried out to explore the distribution of syndrome types and elements and traditional Chinese medicine of TD complicated with ADHD in children.Results:Totally 23 articles were finally included.And 20 syndrome types were obtained,the most frequent syndrome type was Fengtanneirao syndrome,and 16 syndrome elements were extracted.The main syndrome elements of location of the disease were liver,kidney,spleen and heart,and the main syndrome elements of characteristics of the disease were Yangkang,Yinxu,Dongfeng,Waifeng and Tan.After correlation analysis,the combination with the highest support and confidence was Waifeng-Dongfeng.After cluster analysis,five cluster groups were obtained:(1)Tan,Dongfeng,and Waifeng;(2)liver,Yangkang,kidney,and Yinxu;(3)spleen and Qixu;(4)heart,Huo/Re,and Jinkui;(5)stomach,Xuexu,Qizhi,and Jingkui.A total of 98 kinds of traditional Chinese medicine were enrolled,including 14 kinds of traditional Chinese medicine with frequency ≥ 10,and the top 5 in frequency were Baishao,Longgu,Gouteng,Yuanzhi and Tianma.The traditional Chinese medicines were divided into 18 categories,mainly for deficiency-tonifying drugs,rxterior-releasing drugs,heat-clearing drugs,mind-easing drugs,and Xifeng Zhijing drugs,mainly acted on the liver,heart,lung,spleen and kidney.Association analysis and cluster analysis formed a core drug formula based on 9 drugs:Baishao,Shudihuang,Tianma,Gouteng,Shijueming,Quanxie,Zhenzhumu,Longgu and Yuanzhi.Conclusion:The main syndrome elements of location of TD complicated with ADHD in children were liver,kidney,spleen and heart.Yangkang,Yinxu,Dongfeng,Waifeng and Tan are common syndromes.The main therapeutic principles are Yangxue Ziyin,Pinggan Xifeng and Qingre Anshen.The core formulas are Baishao,Shudihuang,Tianma,Gouteng,Shijueming,Quanxie,Zhenzhumu,Longgu and Yuanzhi,which need to be flexibly added or subtracted according to different syndromes in clinic.关键词
抽动障碍/注意力缺陷多动障碍/R语言/证型/证素/中药Key words
tic disorder/attention deficit hyperactivity disorder/R language/syndrome types/syndrome elements/traditional Chinese medicine分类
医药卫生
