儿科药学杂志2025，Vol.31Issue(1)：41-44,4.DOI:10.13407/j.cnki.jpp.1672-108X.2025.01.008
小剂量多巴胺辅助治疗新生儿坏死性小肠结肠炎的临床疗效及对炎症因子水平的影响
Clinical Efficacy of Low-Dose Dopamine in the Adjuvant Treatment of Neonatal Necrotizing Enterocolitis and Effects on Levels of Inflammatory Factors
摘要
Abstract
Objective:To probe into the clinical efficacy of low-dose dopamine in the treatment of patients with neonatal necrotizing enterocolitis(NEC).Methods:Seventy neonates with NEC admitted into our hospital were randomly divided into the control group and observation group,with 35 cases in each group.The control group received octreotide,while the observation group was given low-dose dopamine of 2.5 μg/(kg·min).The total effective rate,improvement of clinical symptoms,inflammatory factors and adverse drug reactions were compared between two groups.Results:The total effective rate of observation group(94.29％)was significantly higher than that of the control group(77.14％,P＜0.01).The time of abdominal distension,diarrhea relief and stool improvement in the observation group was significantly shorter than that in the control group(P＜0.01).The levels of tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-8(IL-8)and IL-6 in observation group were significantly lower than those in control group(P＜0.01).There was no significant difference in the incidence of sleepiness,sweating and other adverse drug reactions between two groups(P＞0.05).Conclusion:Low-dose dopamine in the treatment of neonates with NEC can effectively reduce the inflammatory response and promote the recovery of the prognosis with higher clinical application value.关键词
坏死性小肠结肠炎/新生儿/小剂量/多巴胺/炎症因子Key words
necrotizing enterocolitis/neonates/low-dose/dopamine/inflammatory factors分类
医药卫生引用本文复制引用
张婕,苗耐英,李欢,刘新建..小剂量多巴胺辅助治疗新生儿坏死性小肠结肠炎的临床疗效及对炎症因子水平的影响[J].儿科药学杂志,2025,31(1):41-44,4.基金项目
廊坊市科技支撑计划项目,编号2023013037. （）
