影像科学与光化学2025，Vol.43Issue(1)：10-16,7.DOI:10.7517/issn.1674-0475.2025.01.02
高原适应者不同返回方式脱适应期右心室结构及功能变化研究
Study on the Changes of Right Ventricular Structure and Function in Different Return Modes of Plateau Accommodators during the Period of De-adaptation
摘要
Abstract
Objective:To explore the effects of different return modes on the changes of right ventricular structure and function,and mitigate the adverse effects of high altitudede-adaptationon circulatory system.Methods:A total of 80 soldiers who were stationed in 4000 m plateau for 3 months were divided into two groups:group A(n=40,returned to the plain directly)and group B(n=40,return in steps).During the same period,40 soldiers trained on the plain(100 m above sea level)were selected as the control group,with an average age of(23.89±2.65)years old,and their height and weight were matched with those of the experimental group.Echocardiography was performed before returning to the plain(day 0)and on day 2 and day 15 to evaluate the structure of the right ventricular cavity by measuring the transverse diameter of the right ventricle(RVD)and the inner diameter of the right ventricular outflow tract(RVOT).Right ventricular myocardial function index(RV-Tei)was measured to evaluate right ventricular function.The.right ventricular global longitudinal strain(RVGLS)and the right ventricular free wall strain(RVFWS)were analyzed by two-dimensional speckle tracking imaging technique.Results:On day 2:Compared with the control group,the right heart function of group A and group B decreased(RV-Tei index:group A 0.42±0.03 vs control group 0.31±0.02,P＜0.05;group B 0.40±0.02 vs control group 0.31±0.02,P＜0.05;group A 0.42±0.03 vs group B 0.40±0.02,P＜0.05)and ventricular enlargement(RVD:group A 4.47±0.36 vs control group 3.61±0.30,P＜0.05;group B 4.21±0.58 vs control group 3.61±0.30,P＜0.05;group A 4.47±0.36 vs group B 4.21±0.58,P＜0.05).The right ventricular myocardial deformability decreased.Group B showed more significant improvement.Back on day 15:Compared with day 2,the ventricular cavity of both group A and B was smaller than before,and the improvement was more obvious in group B(RVD:group A 4.40±0.37 vs group B 4.12±0.60,P＜0.05).RVOT in group B and right heart function in groups A and B were restored to plain level.Conclusion:Returning from high altitudes in a stepped descent manner helps reduce the body's oxidative stress levels,improve right ventricular structure and function,and thus reduce the incidence and severity of high-altitude de-adaptation reactions.关键词
高原脱适应/右心室/超声心动图/二维斑点追踪技术Key words
high altitude de-adaptation/right ventricular/echocardiography/two-dimensional speckle tracking imaging technique分类
医药卫生引用本文复制引用
刘丽枝,柴青芬,刘超,王永辉,王玫雯..高原适应者不同返回方式脱适应期右心室结构及功能变化研究[J].影像科学与光化学,2025,43(1):10-16,7.基金项目
河南省医学科技攻关计划科研项目(LHGJ20190878). （LHGJ20190878）
