河北科技大学学报2025，Vol.46Issue(1)：30-40,11.DOI:10.7535/hbkd.2025yx01004
血液透析膜在抗凝血改性方面的研究进展
Research progress on modification of hemodialysis membranes with anticoagulant properties
摘要
Abstract
The dialysis membrane is the most important component of hemodialyzer,and its performance depends on the feasibility and biocompatibility of removing toxic solutes.However,when the membrane material is in contact with blood directly,plasma proteins will quickly adsorb on the surface of the membrane and bind to the glycoprotein receptors on platelets,resulting in platelet activation,coagulation cascade and complement activation.This will inevitably induce coagulation and thrombosis,threatening the health and life safety of patients.In order to confer favorable anticoagulant properties upon hemodialysis membranes,it is imperative to modify the membrane materials,including surface microstructure,surface charge and wettability,thereby ensuring their controllability in terms of blood compatibility.The modification technology of the membrane was summarized.The challenges and improvement strategies faced by hemodialysis membranes in the current stage of anal dilation was elaborated.It was clarified that most of the current anticoagulant modification strategies have the problem of poor stability and easy detachment,while the modification process usually involves the usage of organic solvents and chemicals.This review also puts forward prospect on the developing direction of anticoagulant modification technology for dialysis membranes:1)developing intelligent responsive materials to achieve dynamic anticoagulant functions;2)constructing a biomimetic membrane surface to reduce the body's rejection reaction;3)designing dynamic and renewable surfaces that can self-recover or regenerate;4)carrying out green modification methods which can not only achieve efficient anticoagulant modification but also reduce environmental pollution.关键词
功能高分子材料/血液透析膜/抗凝血/血液相容性/膜表面功能化Key words
functional polymer material/hemodialysis membrane/anticoagulation/blood compatibility/membrane surface functionalization分类
通用工业技术引用本文复制引用
王宣,李泽华,史润婕,李田田,王若琳,牛春梅..血液透析膜在抗凝血改性方面的研究进展[J].河北科技大学学报,2025,46(1):30-40,11.基金项目
国家自然科学基金(22308085) （22308085）
河北省自然科学基金(B2020208083) （B2020208083）
2024年河北省硕士在读研究生创新能力培养资助项目(CXZZSS2024081) （CXZZSS2024081）
