实用临床医药杂志2024，Vol.28Issue(24)：110-115,120,7.DOI:10.7619/jcmp.20243153
狼疮性肾炎患者外周血炎症和免疫调节相关分子水平变化及其预测预后的价值
Change in levels of molecules related to inflammation and immune regulation in peripheral blood of patients with lupus nephritis and their values in predicting prognosis
摘要
Abstract
Objective To analyze the change in levels of high mobility group box 1 protein(HMGB1),interleukin-32(IL-32),matrix metalloproteinase-9(MMP-9)/tissue inhibitor of metal-loproteinase-1(TIMP-1)in peripheral blood of patients with lupus nephritis(LN)and their values in predicting prognosis.Methods A total of 86 patients with LN from October 2021 to June 2023 were selected and treated with induction therapy for 6 months.Based on remission status of the disease,patients were divided into remission group(n=66)and non-responder group(n=20).Baseline da-ta,change in levels and reduction rates of HMGB1,IL-32 and MMP-9/TIMP-1,and the partial cor-relation of reduction rates of HMGB1,IL-32 and MMP-9/TIMP-1 levels in peripheral blood with treatment response as well as their predictive values for treatment response were compared between the two groups.Disease progression was compared between patients with different reduction rates of HMGB1,IL-32 and MMP-9/TIMP-1.Results HMGB1,IL-32 and MMP-9/TIMP-1 levels in the remission group decreased significantly at 1 and 3 months after treatment compared to before treatment(P＜0.05);the levels of HMGB1,IL-32 and MMP-9/TIMP-1 in the remission group were significantly lower than those in the non-responder group at 1 and 3 months after treatment(P＜0.05);the reduction rates of HMGB1,IL-32 and MMP-9/TIMP-1 levels in the remission group were significantly higher than those in the non-responder group at 1 and 3 months after treatment(P＜0.05).Partial correla-tion analysis showed that the reduction rates of HMGB1,IL-32 and MMP-9/TIMP-1 levels were in-dependently significantly correlated with treatment response(P＜0.05).One and three months after treatment,the values of the area under the curve(AUC)for the combined prediction of remission by the reduction rates of HMGB1,IL-32 and MMP-9/TIMP-1 levels were 0.910 and 0.932 respec-tively,with the AUC being the largest at 3 months after treatment(P＜0.05).Patients were divided into high and low reduction rate subgroups based on theoptimal cut-off value from the ROC curve anal-ysis at 3 months after treatment,and the disease progression rate was significantly lower in the high re-duction rate subgroup than in the low reduction rate subgroup for HMGB1,IL-32 and MMP-9/TIMP-1(P＜0.05).Conclusion The great change in levels of HMGB1,IL-32 and MMP-9/TIMP-1 in peripheral blood of LN patients is significantly correlated with treatment response and disease pro-gression,and the combined detections of HMGB1,IL-32 and MMP-9/TIMP-1 levels at 1 and 3 months after treatment have high value in predicting the treatment response of LN patients.关键词
狼疮性肾炎/高迁移率族蛋白B1/白细胞介素-32/基质金属蛋白酶-9/基质金属蛋白酶抑制剂-1/预后/治疗应答Key words
lupus nephritis/high mobility group box 1 protein/interleukin-32/matrix met-alloproteinase-9/tissue inhibitor of metalloproteinase-1/prognosis/treatment response分类
医药卫生引用本文复制引用
朱红红,马中双,刘颖..狼疮性肾炎患者外周血炎症和免疫调节相关分子水平变化及其预测预后的价值[J].实用临床医药杂志,2024,28(24):110-115,120,7.基金项目
江苏省优势学科建设工程项目(YSHL2101-091) （YSHL2101-091）
