实用临床医药杂志2024，Vol.28Issue(23)：36-41,6.DOI:10.7619/jcmp.20242880
基于数据挖掘法探讨原发性肝癌中国肝癌分期方案各期中医治疗用药规律
Medication rules of traditional Chinese medicine treatment in various stages of primary liver cancer of China liver cancer staging based on data mining
摘要
Abstract
Objective To explore and analyze the prescription patterns of Professor Zhou Min in treating primary liver cancer at different stages according to the China Liver Cancer Staging(CNLC)system.Methods The clinical records of outpatients with primary liver cancer treated by Professor Zhou Min were collected and entered into the Traditional Chinese Medicine Inheritance Support System(Version 2.50)to establish a database.Data mining methods such as frequency analysis,drug associ-ation analysis,and cluster analysis were employed,the pathogenesis of primary liver cancer the pre-scription patterns at different stages was explored and medication rules were analyzed according to Pro-fessor Zhou Min's experience in treating liver cancer at various CNLC stages.Results A total of 202 prescriptions from 113 patients with primary liver cancer were collected,involving 230 traditional Chi-nese medicines.The high-frequency drugs and drug combinations at each stage were identified.The drugs with higher frequencies at each stage included Fuling,Chenpi,Yiyiren,fried Baishu,and Fabanxia.For stage Ⅰ,high-frequency drugs also included Zhongjiefeng,Xiangfu,Jiangcan,and Jianghuang.For stages Ⅱ and Ⅲ,high-frequency drugs further encompassed Zhongjiefeng,Xianhe-cao,Banzhilian,Baihua Sheshecao,Jiangcan,Zeqi,Xiangfu,and Maidong.For stage Ⅳ,high-frequency drugs also include Maydis stigma,Huoxiang,fried Maiya,Jineijin,and fried Guya.The majority of the drugs were cold in nature,with sweet and bitter tastes being the most common,and their meridian tropism were mostly distributed in the spleen and stomach meridians.The drug combi-nations with higher frequencies at each stage were mostly derived from Sijunzi Decoction and Erchen Decoction.The drug efficacies were mainly heat-clearing and dampness-resolving.Cluster analysis screened out new prescriptions with unique characteristics at each stage.Conclusion By perform-ing data mining on the prescriptions used by Professor Zhou Min in treating primary liver cancer at various CNLC stages through the Traditional Chinese Medicine Inheritance Platform,combined with his understanding of the pathogenesis and clinical experience of the disease,the pathogenesis char-acteristics of primary liver cancer are summarized as dampness-heat,phlegm,and toxin accumula-tion,as well as qi and yin deficiency.The basic treatment methods established are heat-clearing and dampness-resolving,spleen-invigorating and yin-nourishing,with an emphasis on strengthening the body resistance to eliminate pathogenic factors and stage-based treatment.Flexible prescriptions and medications are used for different complications.关键词
原发性肝癌/中国肝癌分期方案/中医药/数据挖掘Key words
primary liver cancer/China Liver Cancer Staging System/traditional Chinese medicine/data mining分类
医药卫生引用本文复制引用
袁征,杨月艳,霍介格,叶放,方南元,陈沁磊,方晶,何晶..基于数据挖掘法探讨原发性肝癌中国肝癌分期方案各期中医治疗用药规律[J].实用临床医药杂志,2024,28(23):36-41,6.基金项目
江苏省社会发展重点研发计划项目(BE2019723) （BE2019723）
全国名老中医药专家传承工作室建设项目-周珉全国名老中医药专家传承工作室(国中医药人教函[2022]75号) （国中医药人教函[2022]75号）
