检验医学与临床2025，Vol.22Issue(1)：7-11,5.DOI:10.3969/j.issn.1672-9455.2025.01.002
温阳益髓方联合富血小板血浆治疗早中期膝骨关节炎的疗效及对血清S100B、CTX-Ⅱ水平的影响
Effect of warming yang and nourishing marrow formula combined with platelet-rich plasma on the levels of serum S100B and CTX-Ⅱ in the treatment of early and middle stage knee osteoarthritis
摘要
Abstract
Objective To analyze the therapeutic effect of warming yang and nourishing marrow formula com-bined with platelet rich plasma(PRP)in the treatment of early and middle stage knee osteoarthritis(KOA)and its effect on serum S100B and C-terminal peptide of type Ⅱ collagen(CTX-Ⅱ)levels.Methods A total of 150 patients with early and middle KOA admitted to this hospital from April 2021 to January 2023 were selected as the study objects and were divided into the observation group and the control group according to random number table method,with 75 patients in each group.The clinical efficacy,incidence of total adverse reactions,recur-rence rate,Lysholm Knee Function Scale(LKS)score and serum S100B,CTX-Ⅱ levels before treatment and 1 month after treatment,as well as Visual Analog Scale(VAS)score before treatment,1 week after treatment and 1 month after treatment were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the recurrence rate of the observation group was lower than that of the control group,with statistical significance(P＜0.05).After 1 month of treatment,the LKS score of the two groups was higher than that before treatment,and the LKS score of the observation group was higher than that of the control group,with statistical significance(P＜0.05).Repeated measures a-nalysis of variance showed that there was an interaction effect between the changes of VAS scores during the treatment in the two groups(F=20.132,P=0.030),so further separate effect analysis was performed.VAS scores of the control group and the observation group after 1 week and 1 month of treatment were lower than before treatment,and VAS scores of 1 month after treatment were lower than after 1 week of treatment,and the differences were statistically significant(P＜0.05).After 1 month of treatment,serum S100B and CTX-Ⅱlevels in two groups were lower than before treatment,and the observation group was lower than the control group,the differences were statistically significant(P＜0.05).There was no significant difference in the total adverse reaction rate between the two groups(P＞0.05).Conclusion Warming yang and nourishing marrow formula combined with PRP can effectively relieve pain symptoms,improve serum S100B and CTX-Ⅱ levels,promote functional rehabilitation of knee joint and reduce the recurrence rate of the disease,which is worthy of clinical promotion.关键词
膝骨关节炎/温阳益髓方/富血小板血浆/S100B/Ⅱ型胶原C端肽Key words
knee osteoarthritis/warming yang and nourishing marrow formula/platelet rich plasma/S100B/C-terminal peptide of type Ⅱ collagen分类
医药卫生引用本文复制引用
沈建成,刘壮,阮安民,张洪美,何剑全..温阳益髓方联合富血小板血浆治疗早中期膝骨关节炎的疗效及对血清S100B、CTX-Ⅱ水平的影响[J].检验医学与临床,2025,22(1):7-11,5.基金项目
国家自然科学基金项目(82004433) （82004433）
中国中医科学院科技创新工程项目(CI2021A02005). （CI2021A02005）
