| 注册
首页|期刊导航|检验医学与临床|温肾化痰方联合西药治疗对肾虚痰湿型PCOS伴IR不孕症患者性激素、糖代谢、排卵率、妊娠率、疗效及不良反应的影响

温肾化痰方联合西药治疗对肾虚痰湿型PCOS伴IR不孕症患者性激素、糖代谢、排卵率、妊娠率、疗效及不良反应的影响

蔡亚静 王春霞 李鹏超 王洋 程晓艺 余文彩

检验医学与临床2025,Vol.22Issue(1):12-17,6.
检验医学与临床2025,Vol.22Issue(1):12-17,6.DOI:10.3969/j.issn.1672-9455.2025.01.003

温肾化痰方联合西药治疗对肾虚痰湿型PCOS伴IR不孕症患者性激素、糖代谢、排卵率、妊娠率、疗效及不良反应的影响

Effects of Wenshen Huatan decoction combined with Western medicine on sex hormone,glucose metabolism,ovulation rate and pregnancy rate,efficacy and adverse reactions in patients with kidney deficiency phlegm-dampness PCOS and IR infertility

蔡亚静 1王春霞 2李鹏超 2王洋 1程晓艺 1余文彩1

作者信息

  • 1. 河南中医药大学第二临床医学院,河南郑州 450002
  • 2. 河南省中医院生殖医学科,河南郑州 450003
  • 折叠

摘要

Abstract

Objective To analyze the effects of Wenshen Huatan decoction combined with Western medi-cine on sex hormone,glucose metabolism,ovulation rate,pregnancy rate,efficacy and adverse reactions in pa-tients with polycystic ovary syndrome(PCOS)and insulin resistance(IR)infertility.Methods A total of 61 kidney deficiency phlegm-dampness PCOS with IR infertility patients admitted to the Department of Repro-ductive Medicine of Henan Provincial Hospital of Traditional Chinese Medicine from December 2022 to July 2023 were selected as the study objects and randomly divided into the experimental group(31 cases)and the control group(30 cases).The control group was treated with metformin hydrochloride tablets and letrozole tablets,and the experimental group was treated with Wenshen Huatan decoction on the basis of this treat-ment.Both groups were given 3 menstrual cycles.Serum testosterone(T),luteinizing hormone(LH),follicle stimulating hormone(FSH)levels,LH/FSH ratio,body mass index(BMI),fasting blood glucose(FBG),fasting insulin(FINS),homeostasis index model(HOMA-IR),ovulation rate,pregnancy rate and efficacy of patients were observed before and after treatment,and security assessment was carried out.Results Before treatment,there were no significant differences in BMI,HOMA-IR,LH/FSH ratio and serum T,LH,FSH,FBG,FINS levels between the two groups(P>0.05).After treatment,BMI,HOMA-IR,LH/FSH ratio and serum T,LH,FBG and FINS levels in two groups were lower than before treatment,serum FSH level was higher than before treatment,and BMI,HOMA-IR,LH/FSH ratio and serum T,LH,FBG,FINS levels in the experimental group were lower than those in the control group,and serum FSH level in the experimental group was higher than those of the control group,and the differences were statistically significant(P<0.05).The total effective rate,ovulation rate and pregnancy rate of experimental group were higher than those of the control group,and the incidence of total adverse reactions was lower than that of the control group,with sta-tistical significances(P<0.05).Conclusion The efficacy of Wenshen Huatan decoction combined with con-ventional Western medicine in treating infertility associated with kidney deficie-ncy and phlegm-dampness pat-tern of PCOS with IR is superior to conventional Western medicine alone,which can increase ovulation rate and pregnancy rate,improve female sex hormone,glucose metabolism index levels,alleviate IR,improve clini-cal symptoms of traditional Chinese medicine,with good safety.

关键词

不孕症/多囊卵巢综合征/温肾化痰方/胰岛素抵抗/肾虚痰湿型

Key words

infertility/polycystic ovary syndrome/Wenshen Huatan decoction/insulin resistance/kidney deficiency phlegm-dampness

分类

医药卫生

引用本文复制引用

蔡亚静,王春霞,李鹏超,王洋,程晓艺,余文彩..温肾化痰方联合西药治疗对肾虚痰湿型PCOS伴IR不孕症患者性激素、糖代谢、排卵率、妊娠率、疗效及不良反应的影响[J].检验医学与临床,2025,22(1):12-17,6.

基金项目

国家区域中医(专科)诊疗中心建设项目[国中医药办医政函(2017)39号] (专科)

国家中医药管理局高水平中医药学科建设项目[国中医药人教函(2023)85号] (2023)

河南省生殖障碍疾病中医药防治工程研究中心[豫发改高技(2023)484号] (2023)

河南省中医药重点实验室项目[豫卫中医函(2021)30号] (2021)

河南省中医药拔尖人才培养项目[豫卫中医函(2021)15号]. (2021)

检验医学与临床

1672-9455

访问量1
|
下载量0
段落导航相关论文