昆明医科大学学报2025，Vol.46Issue(1)：1-8,8.DOI:10.12259/j.issn.2095-610X.S20250101
巨噬细胞极化在部分血栓性疾病中的作用
The Role of Macrophage Polarization in Thrombotic Diseases
摘要
Abstract
Thrombotic diseases refer to a group of conditions characterized by abnormal blood coagulation within blood vessels,leading to the formation of blood clots and a series of clinical symptoms.This includes diseases such as deep vein thrombosis in the lower extremities,stroke,atherosclerosis,and diabetes.Thrombosis is a complex,progressive process that can be broadly summarized as the exposure of vascular endothelial damage,activation of the intrinsic coagulation system,platelet adhesion and aggregation,fibrin network formation,blood cell stasis.Macrophages play an important role in this process.They are involved in local inflammatory responses,regulating both the formation and resolution of thrombi.Macrophage polarization is a hot research topic in recent years,which mainly refers to the morphological and functional changes of macrophages in response different environmental stimuli.Macrophage polarization can be classified into classical(M1)and alternative(M2)types,as well as several specialized polarization states.The transition of macrophage polarization states plays an important role in immune responses,pathogen infections,tumor immunity,and autoimmune processes.This review discusses the regulatory relationship of macrophage polarization in thrombotic diseases,providing new directions for the treatment of these conditions.关键词
血栓性疾病/深静脉血栓/巨噬细胞/巨噬细胞极化Key words
Thrombotic diseases/Deep vein thrombosis/Macrophages/Macrophage polarization分类
医药卫生引用本文复制引用
申屠昊鹏,杨菁,葛卫清,周涛,宋恩..巨噬细胞极化在部分血栓性疾病中的作用[J].昆明医科大学学报,2025,46(1):1-8,8.基金项目
国家自然科学基金(82160101) （82160101）
