内科理论与实践2024，Vol.19Issue(5)：318-321,4.DOI:10.16138/j.1673-6087.2024.05.06
肾病综合征患者免疫抑制治疗继发侵袭性肺曲霉病1例
Invasive pulmonary aspergillosis secondary to immunosuppressive therapy in nephrotic syndrome:a case report
阮怡霖 1徐天 1冯晓蓓 1徐静 1史浩 1任红1
作者信息
- 1. 上海交通大学医学院附属瑞金医院肾内科,上海 200025
- 折叠
摘要
Abstract
A 61-year-old male with a one-year history of membranous nephropathy was placed on combined therapy of glucocorticoids and rituximab.On the 12th day of treatment,the patient developed high fever,accompanied by mild cough and night sweats.Chest CT revealed multiple nodules and patchy opacities in both lungs.Bronchoalveolar lavage fluid(BALF)analysis using next-generation sequencing(NGS)identifed Aspergillus infection,and two consecutive β-D-glucan tests were positive.The clinical diagnosis of invasive pulmonary aspergillosis(IPA)was established.The patient received intravenous voriconazole for six months.Follow-up chest CT showed significant absorption of pulmonary lesions.The treatment regimen led to recovery of the patient and achieved partial remission of nephrotic.关键词
膜性肾病/侵袭性肺曲霉病/免疫抑制治疗/利妥昔单抗/二代测序Key words
Membranous nephropathy/Invasive pulmonary aspergillosis/Immunosuppressive therapy/Rituximab/Next-generation sequencing分类
医药卫生引用本文复制引用
阮怡霖,徐天,冯晓蓓,徐静,史浩,任红..肾病综合征患者免疫抑制治疗继发侵袭性肺曲霉病1例[J].内科理论与实践,2024,19(5):318-321,4.
