昆明医科大学学报2025，Vol.46Issue(1)：123-128,6.DOI:10.12259/j.issn.2095-610X.S20250118
儿童肥胖症中IGF-1和IGFBP-3的水平及诊断价值
Levels of IGF-1 and IGFBP-3 in Childhood Obesity and Their Diagnostic Value
摘要
Abstract
Objective To explore the expression changes of IGF-1 and IGFBP-3 in childhood obesity and their diagnostic value.Methods Blood samples and corresponding clinical information were collected from patients attending Kunming Children's Hospital from December 2023 and March 2024,and were divided into a control group(healthy children;n=115)and a study group(obese children;n=86).Serum levels of IGF-1 and IGFBP-3 in both groups were measured by using ELISA.Clinical data from both groups were analyzed to assess the correlation between IGF-1 and IGFBP-3 and clinical information,as well as their diagnostic value in childhood obesity.Results Compared to the control group,the study group exhibited a significant increase in weight and BMI(P<0.001)while IGF-1 and IGFBP-3 levels were significantly lower(P<0.05).IGF-1 levels exhibited a negative correlation with total cholesterol,triglycerides,apolipoprotein B,and insulin resistance index(P<0.05),and a positive correlation with apolipoprotein A and fasting insulin(P<0.05);IGFBP-3 displayed the opposite pattern(P<0.05).ROC diagnostic curves indicated that the area under the curve for IGF-1 and IGFBP-3 was 0.598 and 0.665,respectively.Conclusion IGF-1 and IGFBP-3 are expressed at low levels in childhood obesity and are associated with obesity indicators,demonstrating certain diagnostic value.关键词
儿童肥胖症/诊断/IGF-1/IGFBP-3Key words
Childhood obesity/Diagnosis/IGF-1/IGFBP-3分类
医药卫生引用本文复制引用
罗丽丝,杨清雄,王燕,刘四香,许榛,凌昱..儿童肥胖症中IGF-1和IGFBP-3的水平及诊断价值[J].昆明医科大学学报,2025,46(1):123-128,6.基金项目
昆明市卫生健康委员会卫生科研课题(2023-06-01-031) （2023-06-01-031）
