昆明医科大学学报2025，Vol.46Issue(1)：142-147,6.DOI:10.12259/j.issn.2095-610X.S20250121
CD4+CD25+Treg、sCD30与淋巴瘤临床特征关系及预测化疗后感染价值
Correlations between CD4+CD25+Treg,sCD30 and Clinical Characteristics of Lymphoma and Their Value in Predicting Infection after Chemotherapy
摘要
Abstract
Objective To investigate the expression and significance of CD4+CD25+regulatory T cells(CD4+CD25+Treg)and soluble CD30(sCD30)in peripheral blood of lymphoma patients.Methods A total of 83 lymphoma patients admitted to Beijing Aerospace General Hospital from January 2018 to December 2022 were selected as the research subjects,and their peripheral blood CD4+CD25+Treg and sCD30 expressions were statistically analyzed.Spearman analysis was used to investigate the correlation between peripheral blood CD4+CD25+Treg and sCD30 expressions and bone marrow infiltration.At the same time,the research subjects were divided into an infection group(n=26)and a non-infection group(n=57)according to the presence or absence of infection after rituximab chemotherapy.The expressions and differences of peripheral blood CD4+CD25+Treg and sCD30 in the two groups were compared,and the receiver operating characteristic(ROC)curve and area under the curve(AUC)were used to analyze the predictive efficacy.Results The expression of CD4+CD25+Treg and sCD30 in peripheral blood of patients with bone marrow infiltration was higher than that of patients without bone marrow infiltration in the research group(P<0.05);the expression of CD4+CD25+Treg and sCD30 in peripheral blood of lymphoma patients was positively correlated with bone marrow infiltration(r=0.612,0.634,P<0.05);the expression of Tregs and sCD30 in peripheral blood of the infection group after chemotherapy was higher than that of the non-infection group,and the difference was higher than that of the non-infection group(P<0.05);the ROC curve showed that the combined prediction of the difference of CD4+CD25+Treg and sCD30 in peripheral blood for the infection after chemotherapy in lymphoma patients had an AUC of 0.916(0.834～0.965),which was superior to single prediction.Conclusion The high expression of CD4+CD25+Treg and sCD30 in peripheral blood of lymphoma patients is positively correlated with bone marrow infiltration.Combined testing can improve the predictive efficacy of infection after chemotherapy and guide clinical diagnosis and treatment.关键词
淋巴瘤/骨髓浸润/化疗/感染/CD4+CD25+Treg/sCD30Key words
Lymphoma/Bone marrow infiltration/Chemotherapy/Infection/CD4+CD25+Treg/sCD30分类
医药卫生引用本文复制引用
刘春艳,常炳庆,李超,任欣,刘小琴..CD4+CD25+Treg、sCD30与淋巴瘤临床特征关系及预测化疗后感染价值[J].昆明医科大学学报,2025,46(1):142-147,6.基金项目
北京航天总医院创新基金(2020-605) （2020-605）
