内科理论与实践2024，Vol.19Issue(5)：351-356,6.DOI:10.16138/j.1673-6087.2024.05.13
中药通过干预铁死亡治疗帕金森病的机制研究进展
Research progress on mechanism of traditional Chinese medicine in treating Parkinson disease by interfering with ferroptosis
摘要
Abstract
Ferroptosis is a newly recognized form of programmed cell death in recent years,and its core mechanism mainly involves the accumulation of iron-dependent lipid peroxides in cells.More and more studies suggest that ferroptosis plays a critical role in the onset and progression of Parkinson disease(PD).This article aims to review the molecular regulatory mechanism of ferroptosis in detail and the latest research progress on ferroptosis in treatment of PD and the therapeutic methods of traditional Chinese medicine for it.Through in-depth discussion of this emerging research field,the current status and progress of active ingredients and compounds of traditional Chinese medicine intervening process of PD through ferroptosis pathway were summarized,which was expected to provide a solid theoretical basis and innovative ideas for the application of targeting ferroptosis in the PD treatment.关键词
铁死亡/帕金森病/脂质过氧化/铁代谢/α-突触核蛋白Key words
Ferroptosis/Parkinson disease/Lipid peroxidation/Iron metabolism/Alpha-synuclein分类
医药卫生引用本文复制引用
李媛媛,姚小玲,曲彦洁,陈敬贤..中药通过干预铁死亡治疗帕金森病的机制研究进展[J].内科理论与实践,2024,19(5):351-356,6.基金项目
国家自然科学基金项目(82001341) （82001341）
上海市第七批全国老中医药专家学术经验继承工作项目(国中医药办人教函[2021]272号) （国中医药办人教函[2021]272号）
2022年上海市"医苑新星"青年医学人才培养资助计划(沪卫人事[2023]62号) （沪卫人事[2023]62号）
上海市市级名中医工作室基层工作站建设项目(JCGZZ-2023007) （JCGZZ-2023007）
上海市名中医沈小珩普陀传承工作室 （）
