器官移植2025，Vol.16Issue(1)：169-173,5.DOI:10.12464/j.issn.1674-7445.2024223
实体器官移植术后卡波西肉瘤研究进展
Research progress on Kaposi sarcoma after solid organ transplantation
摘要
Abstract
Kaposi sarcoma is an endothelial cell-derived malignant tumor caused by latent infection with human herpesvirus 8(HHV-8)and reactivation under host immunosuppression.Solid organ transplant recipients are a high-risk group for Kaposi sarcoma.Compared with non-organ transplant recipients,post-transplant Kaposi sarcoma is often more aggressive and visceral involvement is more common.However,due to the relative rarity of Kaposi sarcoma after transplantation,routine pre-transplant serological screening for HHV-8 antibodies in donors and recipients and post-transplant prophylaxis for high-risk groups have not yet been carried out.And there is a lack of experience in the diagnosis and treatment of post-transplant Kaposi sarcoma.This article reviews the epidemiology,clinical manifestations,pathogenesis,diagnosis and treatment experience of Kaposi sarcoma in solid organ transplant recipients in recent years,aiming to attract the attention of transplant physicians and provide a reference for the diagnosis and treatment of this disease.关键词
卡波西肉瘤/实体器官移植/人类疱疹病毒8型/卡波西肉瘤相关疱疹病毒/潜伏期相关核抗原/哺乳动物雷帕霉素靶蛋白抑制剂/紫杉醇/多柔比星Key words
Kaposi sarcoma/Solid organ transplantation/Human herpesvirus 8/Kaposi sarcoma-associated herpesvirus/Latency-associated nuclear antigen/Mammalian target of rapamycin inhibitor/Paclitaxel/Doxorubicin分类
医药卫生引用本文复制引用
方翊灵,苗芸..实体器官移植术后卡波西肉瘤研究进展[J].器官移植,2025,16(1):169-173,5.基金项目
国家自然科学基金(82270784) （82270784）
