内蒙古民族大学学报（自然科学版）2025，Vol.40Issue(1)：53-57,5.DOI:10.14045/j.cnki.15-1220.2025.01.008
蓖麻油对阿霉素诱导扩张型心肌病心力衰竭大鼠心肌电生理作用
Electrophysiological Effects of Castor Oil on Adriamycin Induced Dilated Cardiomyopathy in Rats with Heart Failure
摘要
Abstract
In order to determine the cardiac safety of castor oil in patients with heart failure combined with con-stipation,rats were divided into a normal control group and an adriamycin-induced dilated cardiomyopathy group by using animal experiments,the effects of dimethylsulfoxide(DMSO)and DMSO+castor oil on electrocardiogram(ECG),left ventricular conduction velocity and conduction dispersion degree of isolated perfused hearts of normal rats and adriamycin-induced dilated cardiomyopathy rats were recorded and analyzed by multi-channel electrical mapping technique.The results showed that castor oil had no significant effect on electrocardiogram(ECG),left ven-tricular conduction velocity and conduction dispersion in normal rats and adriamycin-induced dilated cardiomyopa-thy rats.Therefore,castor oil did not trigger arrhythmia in normal rats and adriamycin-induced dilated cardiomyopa-thy rats,and the use of castor oil in patients with heart failure combined with constipation was safe and effective.关键词
DMSO/蓖麻油/扩张型心肌病/多通道电标测系统/心律失常Key words
DMSO/castor oil/dilated cardiomyopathy/multi-channel electrical mapping system/arrhythmia分类
医药卫生引用本文复制引用
杨松骜,金禹辰,杜建军,贺智慧,徐昊阳,田迅..蓖麻油对阿霉素诱导扩张型心肌病心力衰竭大鼠心肌电生理作用[J].内蒙古民族大学学报（自然科学版）,2025,40(1):53-57,5.基金项目
内蒙古自治区开放基金计划项目(MDK202203) （MDK202203）
