上海针灸杂志2025，Vol.44Issue(1)：56-63,8.DOI:10.13460/j.issn.1005-0957.2025.01.0056
针刺治疗卒中后痴呆的疗效观察及对氧化应激激素水平和血流变学的影响
Observation on the efficacy of acupuncture in treating post-stroke dementia and its effect on oxidative stress hormone level and blood rheology
摘要
Abstract
Objective To observe the clinical efficacy of Tianshen-Yizhi acupuncture in treating post-stroke dementia(PSD)with phlegm and blood stasis obstruction pattern and its effects on oxidative stress hormone levels and blood rheology.Method Ninety-four patients with phlegm and blood stasis obstruction pattern PSD were randomly divided into the basic treatment group(31 cases),the control group(32 cases)and the observation group(31 cases).The basic treatment group was given conventional internal medicine treatment,the control group was treated with conventional acupuncture on the basis of the basic treatment group,and the observation group was treated with the Tiaoshen-Yizhi acupuncture on the basis of the basic treatment group.The Montreal cognitive assessment(MoCA),mini-mental state examination(MMSE)scores,Chinese medicine syndrome scores,activities of daily living(ADL)scale scores,oxidative stress level[superoxide dismutase(SOD)and malondialdehyde(MDA)],lipid level[triglyceride(TG),total cholesterol(TC),and low density lipoprotein cholesterol(LDL-C)],blood rheological indexes(whole blood high viscosity,whole blood low viscosity,plasma viscosity)were observed before and after the treatment in the three groups,and the clinical efficacy of the three groups were compared.Result The total effective rate of the observation group was better than that of the remaining two groups,and the difference was statistically significant(P＜0.05).The MoCA and MMSE scores of the three groups were higher than those before treatment(P＜0.05),and the observation group was higher than that of the remaining two groups(P＜0.05).In the observation and control groups,the Chinese medicine syndrome scores were significantly lower than those before treatment(P＜0.05);in the basic treatment group,except for bloatedness,the TCM scores were significantly lower than those before treatment(P＜0.05);the Chinese medicine syndrome scores of the observation group were lower than those of the remaining two groups except for bloatedness(P＜0.05).The ADL scores of the 3 groups were higher than those before treatment,and the difference was statistically significant(P＜0.05);the difference was not statistically significant(P＞0.05)when comparing the ADL scores of the 3 groups after treatment.The serum SOD levels of the three groups after treatment increased compared with that before treatment(P＜0.05),and the SOD level of the observation group was higher than that of the remaining two groups(P＜0.05);the MDA levels of the three groups after treatment decreased compared with that before treatment(P＜0.05),and the MDA level of the observation group was lower than that of the remaining two groups(P＜0.05).The serum TG,TC and LDL-C levels of the three groups were lower than those before treatment(P＜0.05),and those of the observation group was lower than those of the remaining two groups(P＜0.05).The whole blood high viscosity,whole blood low viscosity and plasma viscosity of the three groups were lower than those before treatment(P＜0.05),and the observation group was lower than the remaining two groups(P＜0.05).Conclusion On the basis of conventional internal medicine treatment,the treatment of phlegm and blood stasis obstruction pattern PSD by Tiaoshen-Yizhi acupuncture can improve the patients'MoCA and MMSE scores,Chinese medicine syndrome scores,oxidative stress hormone levels,blood lipid levels and blood rheology indexes.关键词
针刺疗法/针药并用/调神益智/痴呆/中风后遗症Key words
Acupuncture therapy/Acupuncture-medication combined/Tiaoshen-Yizhi(Regulating the spirit and improve the wisdom)/Dementia/Post-stroke sequelae分类
医药卫生引用本文复制引用
李洁,陈云飞,王栩,刘臻,张智龙..针刺治疗卒中后痴呆的疗效观察及对氧化应激激素水平和血流变学的影响[J].上海针灸杂志,2025,44(1):56-63,8.基金项目
国家自然科学基金项目(81904300) （81904300）
上海市科学委员会项目(21ZR1464300) （21ZR1464300）
