上海针灸杂志2024，Vol.43Issue(12)：1331-1336,6.DOI:10.13460/j.issn.1005-0957.2024.12.1331
针刺联合药物治疗肠易激综合征的疗效观察及对胃肠道免疫功能和血清PRDX1水平的影响
Therapeutic observation of acupuncture plus medication in treating irritable bowel syndrome and the effects on gastrointestinal immune function and the serum PRDX1 level
摘要
Abstract
Objective To observe the clinical efficacy in treating irritable bowel syndrome(IBS)with Dongyuan needling method plus Live combined Bifidobacterium,Lactobacillus and Enterococcus capsules and the effects on the patient's gastrointestinal symptoms,immune function,and serum recombinant peroxiredoxin 1(PRDX1)level.Method Ninety-six IBS patients were recruited and randomized into a control group and a research group,with 48 cases in each group.The control group was treated with Live combined Bifidobacterium,Lactobacillus and Enterococcus capsules,and the research group received the capsules along with Dongyuan needling method.The clinical efficacy was compared between the two groups.Before and after the treatment,both groups were observed for changes in the symptom and sign score of traditional Chinese medicine(TCM),gastrointestinal symptom score,IBS symptom severity scale(IBS-SSS)score,serum immune indicator levels[CD4﹢,CD8﹢,CD4﹢/CD8﹢,tumor necrosis factor-α(TNF-α),and interleukin-18(IL-18)],and serum PRDX1 level.Result The research group had a higher total effective rate than the control group(P＜0.05).After the intervention,the scores of TCM symptom and sign,gastrointestinal symptom,and IBS-SSS were lower in the research group than in the control group(P＜0.05);the serum CD4﹢ and CD4﹢/CD8﹢levels were higher(P＜0.05),and the serum CD8﹢ level was lower in the research group(P＜0.05);the serum levels of PRDX1,TNF-α,and IL-18 were lower in the research group(P＜0.05).Conclusion Incorporating Dongyuan needling method into Live combined Bifidobacterium,Lactobacillus and Enterococcus capsules can produce more significant clinical efficacy in treating IBS compared to using the capsule alone;this combined treatment can better improve gastrointestinal symptoms,fortify immune function,and down-regulate the serum PRDX1 level.关键词
针刺疗法/针药并用/肠易激综合征/腹痛/腹泻/便秘Key words
Acupuncture therapy/Acupuncture medication combined/Irritable bowel syndrome/Abdominal pain/Diarrhea/Constipation分类
医药卫生引用本文复制引用
段婉娥,张齐娟,李婉莹,刘正茂,余晗,吴赛,何青,田雨..针刺联合药物治疗肠易激综合征的疗效观察及对胃肠道免疫功能和血清PRDX1水平的影响[J].上海针灸杂志,2024,43(12):1331-1336,6.基金项目
武汉市卫生和计划生育委员会临床医学科研项目(WZ15C09) （WZ15C09）
