实用医学杂志2025，Vol.41Issue(1)：141-145,5.DOI:10.3969/j.issn.1006-5725.2025.01.023
骨形态发生蛋白信号通路在中枢神经系统中的研究进展
Research progress of bone morphogenetic protein signaling pathway in central nervous system
摘要
Abstract
Bone morphogenetic proteins are a large subclass of the transforming growth factor β family,and Their signaling pathways are mainly classified into two kinds based on whether they depend on Smad protein to mediate or not.BMP signaling pathways are involved in regulating cell proliferation and differentiation,as well as the formation and development of multiple tissues and organs.Recent studies have shown that BMP signaling path-ways mainly promote the differentiation and growth of neurons and astrocytes,and are closely related to the my-elination of oligodendrocytes.In addition,BMP signaling pathways also play an important role in the occurrence of central nervous system diseases,such as spinal cord injuries,multiple sclerosis,neural tube defects,and Parkin-son's disease.This article reviews the BMP signaling pathways'composition,transduction mechanism and their role in the central nervous system and related diseases,in order to provide more potential ideas for basic research and clinical treatment of central nervous system diseases.关键词
BMP信号通路/中枢神经系统/脊髓损伤/神经管畸形Key words
BMP signaling pathway/central nervous system/spinal cord injuries/neural tube defects分类
医药卫生引用本文复制引用
甘颖盈,胡敏,崔淑雅,柴智,樊慧杰..骨形态发生蛋白信号通路在中枢神经系统中的研究进展[J].实用医学杂志,2025,41(1):141-145,5.基金项目
国家自然科学基金项目(编号:81703978) （编号:81703978）
国家中医药管理局青年岐黄学者培养项目(编号:国中医药人教函[2022]256号) （编号:国中医药人教函[2022]256号）
山西省科技创新团队专项基金项目(编号:202304051001019) （编号:202304051001019）
山西省重点国别科技合作项目(编号:202204041101002) （编号:202204041101002）
山西省青年拔尖人才支持计划项目(编号:晋组办字[2019]35号文) （编号:晋组办字[2019]35号文）
山西省自然科学基金项目(编号:20210302124293,202203021212346,202203021222269) （编号:20210302124293,202203021212346,202203021222269）
山西省省筹资金资助回国留学人员科研项目(编号:2021-142) （编号:2021-142）
山西中医药大学科技创新能力培育项目(编号:2020PY-JC-03,2022PY-TH-16) （编号:2020PY-JC-03,2022PY-TH-16）
