中国肺癌杂志2024，Vol.27Issue(11)：826-830,5.DOI:10.3779/j.issn.1009-3419.2024.102.39
STMN1表达与非小细胞肺癌预后价值的meta分析
Prognostic Value of STMN1 Expression in Non-small Cell Lung Cancer:A Meta-analysis
摘要
Abstract
Background and objective Lung cancer is one of the malignant tumors with the highest morbidity and mortality rates worldwide,seriously threatening human health.Non-small cell lung cancer(NSCLC)accounts for more than 85％of all lung cancer cases.STMN1 is a microtubule depolymerizing protein widely present in the cytoplasm and its expres-sion level is associated with the prognosis of NSCLC patients.Through meta-analysis,this study aimed to investigate the predic-tive value of the expression level of STMN1 for the prognosis of lung cancer and screen for tumor markers with high sensitivity and specificity to optimize the whole-process management of lung cancer patients.Methods The PubMed,The Cochrane Library,Embase,WanFang and CNKI databases were searched from the inception to Sep 6,2024 for relevant literature.The quality of included studies was assessed by the Newcastle-Ottawa Scale(NOS)score.The hazard ratio(HR)with 95％CI was combined to assess the relationship between STMN 1 expression and prognostic factors.The prognostic indicators included the overall survival(OS)and disease-free survival(DFS).All statistical analysis was conducted by the STATA 17.0 software.Re-sults A total of 5 high-quality studies(NOS score≥6 points)involving 754 patients were enrolled.The pooled results demon-strated that overexpression of STMN1 was significantly related to worse OS(HR=2.28,95％CI:1.79-2.91,P＜0.001)and DFS(HR=2.14,95％CI:1.45-3.17,P＜0.001).Overexpression of STMN1 was a risk factor for poor prognosis of NSCLC patients.Conclusion Overexpression of STMN1 is a poor prognostic factor in NSCLC patients.STMN1 may serve as a prognostic biomarker for NSCLC patients.However,more researches are still needed to verify the above findings.关键词
肺肿瘤/STMN1/预后/Meta分析Key words
Lung neoplasms/STMN1/Prognosis/Meta-analysis引用本文复制引用
李梦洁,周清华..STMN1表达与非小细胞肺癌预后价值的meta分析[J].中国肺癌杂志,2024,27(11):826-830,5.基金项目
本研究受天津市医学重点学科(专科)建设项目(No.TJYXZDXK-010A)资助 This study was supported by the grant from Tianjin Key Medical Discipline(Specialty)Construction Project(No.TJYXZDXK-010A)(to Tianjin Medical University Cancer Institute & Hospital). （专科）
