中国实用内科杂志2024，Vol.44Issue(12)：1018-1025,8.DOI:10.19538/j.nk2024120110
基线和时间依赖血红蛋白水平与中国慢性肾脏病患者主要临床结局的相关性分析
Association of baseline and time-updated hemoglobin with major clinical outcomes in patients with chronic kidney disease in China
摘要
Abstract
Objective To evaluate the association of baseline and time-updated hemoglobin(Hb)with end-stage kidney disease(ESKD),all-cause mortality,and cardiovascular events.Methods This study was based on the Chinese Cohort Study of Chronic Kidney Disease.A total of 3413CKD patientswith complete baseline dataand 914 CKD patients with baseline data and at least 2 follow-up records each yearfrom 39 centers between Nov.2011 and Oct.2016 were included as the research subjects.Multivariable Cox proportional hazards regression models were applied to analyze the association of baseline and time-updated Hbwith the occurrence of ESKD,cardiovascular events and all-cause mortality.ResultsAfter multivariable adjustment,both baseline(HR=1.14,95％CI 1.08-1.20)and time-updated Hb(HR=1.51,95％CI 1.35-1.70)were associated with the risk of ESKD,and the association of time-updated Hb was more significant.Only baseline Hb,not time-updated Hb,was associated with all-cause death(HR=1.14,95％CI 1.03-1.25).Baseline Hb was associated with the risk of congestive heart failure(HR=1.16,95％CI 1.02-1.33).ConclusionIn Chinese patients with stage 1-4 CKD,low baseline and time-updated Hb level is independently associated with the increased risk of ESKD.The association of anemia with congestive heart failure and all-cause mortality is only significant in single Hb evaluation,and the effects of long-term exposure need further study.关键词
慢性肾脏病/贫血/终末期肾脏病/心血管疾病/全因死亡/队列研究Key words
chronic kidney disease/anemia/end stage kidney disease/cardiovascular disease/all-cause mortality/cohort study分类
医药卫生引用本文复制引用
杨丽平,张路霞,高碧霞,王芳,赵明辉,李深,王晋伟..基线和时间依赖血红蛋白水平与中国慢性肾脏病患者主要临床结局的相关性分析[J].中国实用内科杂志,2024,44(12):1018-1025,8.基金项目
科技部国家重点研发计划项目(2020YFC2005003) （2020YFC2005003）
国家自然科学基金项目(82374277,72125009,91846101,81771938,81900665,82003529,82090021) （82374277,72125009,91846101,81771938,81900665,82003529,82090021）
中国科技创新计划2030(2018AAA0102100) （2018AAA0102100）
密歇根大学卫生系统-北京大学卫生科学中心转化与临床联合研究所(BMU2018JI012,BMU2019JI005) （BMU2018JI012,BMU2019JI005）
中科院医学科学创新基金(2019-I2M-5-046) （2019-I2M-5-046）
北大-百度基金(2019BD017,2020BD004,2020BD005) （2019BD017,2020BD004,2020BD005）
中央级公益性科研院所基本科研业务费专项(ZZ13-YQ-025) （ZZ13-YQ-025）
