中国实用儿科杂志2024，Vol.39Issue(12)：894-900,7.DOI:10.19538/j.ek2024120603
卡介苗病免疫评估及临床管理专家共识
Expert consensus on immune assessment and clinical management of BCG vaccine disease
摘要
Abstract
Bacillus calmette-guerin(BCG)disease is an abnormal reaction that may occur after inoculation with the BCG vaccine,especially in immunodeficient children.Inborn Errors of Immunity Alliance of National Children's Medical and Clinical Research Center(IEI.CHN)has developed an expert consensus to standardize the diagnosis and treatment of BCG disease.The consensus states that BCG disease can be divided into local infection,regional infection,distant infection and disseminated infection.The diagnosis is based on BCG vaccination history,clinical presentation,and etiological or pathological evidence.Assessment of immune function is critical in children with distant and disseminated infections.Therapeutically,prophylactic anti-tuberculosis therapy is recommended for immunodeficient children susceptible to BCG.For IEI patients with BCG disease,long-term anti-tuberculosis therapy is required.Some types of IEI require radical treatment by hematopoietic stem cell transplantation.The consensus also highlights the importance of immunotherapy,especially for Mendelian genetic mycobacterium susceptibility diseases with reduced interferon-gamma production.关键词
卡介苗/出生免疫缺陷/慢性肉芽肿病/重症联合免疫缺陷病/孟德尔遗传分枝杆菌易感性疾病/诊断/治疗Key words
BCG/inborn errors of immunity/chronic granulomatous disease/severe combined immunodeficiency disease/Mendelian susceptibility to mycobacterial disease/diagnosis/treatment分类
医药卫生引用本文复制引用
国家儿童医学暨临床研究中心出生免疫缺陷(IEI)联盟,孙金峤,唐雪梅,王晓川,吴洋意,杨军,应文静,张伟,黄文彦,金燕樑,李克莉,李晓忠,凌云,卢美萍,毛华伟,孙碧君..卡介苗病免疫评估及临床管理专家共识[J].中国实用儿科杂志,2024,39(12):894-900,7.基金项目
国家重点研发计划项目(2022YFC2704905) （2022YFC2704905）
上海市市级科技重大专项"重大突发传染病防控关键核心技术研究"项目(ZD2021CY001) （ZD2021CY001）
