中国中医药信息杂志2025，Vol.32Issue(1)：192-196,5.DOI:10.19879/j.cnki.1005-5304.202312063
中药调控铁死亡治疗动脉粥样硬化研究进展
Research Progress in Chinese Materia Medica Regulating Ferroptosis for the Treatment of Atherosclerosis
摘要
Abstract
Atherosclerosis is a chronic vascular disease caused by lipid deposition in the inner wall of blood vessels.Ferroptosis is a non-apoptotic form of cell death characterized by iron dependence and lipid reactive oxygen accumulation.Recent studies have shown that ferroptosis is closely related to the occurrence and development of atherosclerosis.This article explained the correlation between ferroptosis and atherosclerosis from the aspects of foam cell formation,endothelial cell death,vascular smooth muscle proliferation and calcification,and believed that ferroptosis runs through its pathological process.By combing the current research status of the mechanism of Chinese materia medica regulating ferroptosis to treat atherosclerosis,it can be seen that TCM monomers and compounds can reduce endothelial cell dysfunction and inflammatory response,slow down oxidative stress levels,and reduce the accumulation of oxidized lipids under the intima of arterial blood vessels by regulating ferroptosis p53,Nrf2 signaling pathway,amino acid metabolism,lipid metabolism,etc.,so that the blood vessels reach homeostasis,which can provide a reference for the exploration of clinical treatment strategies for atherosclerosis.关键词
中药/铁死亡/动脉粥样硬化/综述Key words
Chinese materia medica/ferroptosis/atherosclerosis/review分类
医药卫生引用本文复制引用
王慧影,王绍娜,张良,付海鑫,兰瑞,武继涛..中药调控铁死亡治疗动脉粥样硬化研究进展[J].中国中医药信息杂志,2025,32(1):192-196,5.基金项目
国家自然科学基金(81973618) （81973618）
