中国合理用药探索2024，Vol.21Issue(12)：32-37,6.DOI:10.3969/j.issn.2096-3327.2024.12.006
2000～2021年某院耐碳青霉烯类鲍曼不动杆菌分离情况和耐药性变迁
Isolation and Resistance Changes of Carbapenem-Resistant Acinetobacter baumannii in a Hospital from 2000 to 2021
吴泉明 1陈发林 1陈东杰 1陈艺真 1陈渝 1吴长生1
作者信息
- 1. 福建医科大学省立临床医学院,福州大学附属省立医院,福州 350001
- 折叠
摘要
Abstract
Objective:To investigate the isolation and resistance changes resistance of carbapenem-resistant Acinetobacter baumannii(CRAB)in a hospital.Methods:Data from CRAB isolates collected in hospital between 2000 and 2021 were analyzed using WHONET5.6 software.Clinical data were retrieved from the hospital's laboratory information system for sorting and analysis.Results:A total of 3692 CRAB strains were obtained,with 62.5% originating from the intensive care unit(ICU)and 79.6% isolated from lower respiratory tract specimens.The detection rates of CRAB varied significantly over time and can be categorized into four distinct stages:during the trough period from 2000 to 2006,fewer than 10 strains were detected annually;during the climbing period from 2007 to 2011,an average of approximately 113 strains were detected per year;during the peak period from 2012 to 2017,the average increased to about 380 strains per year,accounting for 61.9% of the total detected cases;during the decline period from 2018 to 2021,there was a slight decrease,with an average of about 200 strains detected annually.The resistance rates of CRAB to commonly used clinical antibiotics are predominantly above 70.0%,with significant variations observed across different stages.The resistance rate of tigecycline ranged from 6.7% to 15.6%,while the resistance rates of amikacin and compound sulfamethoxazole have shown a decline.Conclusion:Despite a decrease in the current incidence of CRAB infections,the situation remains concerning.CRAB demonstratedsignificant resistance to commonly used antibiotics,necessitating strengthened hospital infection control measures,rational use of antibiotics,and enhanced multidisciplinary collaboration to prevent infections and mitigate drug resistance.关键词
碳青霉烯类/鲍曼不动杆菌/抗菌药物/耐药性/耐药监测Key words
carbapenems/Acinetobacter baumannii/antibiotics/drug resistance/resistance surveillance分类
医药卫生引用本文复制引用
吴泉明,陈发林,陈东杰,陈艺真,陈渝,吴长生..2000～2021年某院耐碳青霉烯类鲍曼不动杆菌分离情况和耐药性变迁[J].中国合理用药探索,2024,21(12):32-37,6.
