中国中医药信息杂志2025，Vol.32Issue(1)：40-48,9.DOI:10.19879/j.cnki.1005-5304.202405244
基于SYRCLE工具和ARRIVE 2.0指南的中药复方防治胃癌前病变动物实验文献质量评价
Evaluation on the Quality of Animal Experimental Literature about the Prevention and Treatment of Precancerous Lesions of Gastric Cancer with TCM Compounds Based on SYRCLE Tool and ARRIVE 2.0 Guideline
摘要
Abstract
Objective To analyze the risk of bias during the experimental process and the shortcomings of the research report by evaluating the methodological and reporting quality of animal experimental studies on the prevention and treatment of precancerous lesions of gastric cancer(PLGC)using TCM compounds.To provide reference for improving the quality of animal experimental research on the prevention and treatment of PLGC with TCM compounds.Methods Experimental literature about the prevention and treatment of PLGC with TCM compounds was retrieved from CNKI,Wanfang Data,VIP,CBM,PubMed,Cochrane Library,Web of science and Embase from January 1,2014 to February 23,2024.SYRCLE assessment tool and ARRIVE 2.0 guideline were used to score the included literature and calculate the"low-risk"compliance rate for each item.Results Totally 213 articles were finally included,including 189 Chinese articles and 24 English articles.The SYRCLE tool score was(12.86±1.29)points,and the"low risk"compliance rate was 32.79％.The score of the necessary items of the ARRIVE 2.0 guideline was(24.15±2.80)points,and the"low risk"compliance rate was 49.08％;the score of the recommended items was(11.28±3.40)points,and the"low risk"compliance rate was 30.27％.In the SYRCLE tool evaluation,144(67.61％)studies did not elaborate on the method of generating the allocation sequence.All studies did not describe the adequacy of allocation concealment and the blinding method in the implementation of bias.Only 51 studies(23.94％)explicitly proposed the success criteria for PLGC modeling,only 66 studies(30.96％)provided detailed information on the statistical methods used,29 studies(13.62％)provided complete ethical statements,and 22 studies(10.33％)reported conflicts of interest.Conclusion There are many problems in the methodological quality and reporting quality of animal experimental literature on the prevention and treatment of PLGC with TCM compounds published from 2014 to 2024,especially the implementation of the random blinding strategy during the experimental process,the calculation details of the sample size,and the reporting of inclusion and exclusion criteria,etc.There are many deficiencies in this aspect.It is recommended to refer to the SYRCLE evaluation tool and the ARRIVE 2.0 guideline list to design and report the research plan,thereby improving the credibility and standardization of the PLGC animal experimental research results.关键词
胃癌前病变/中药复方/动物实验/SYRCLE工具/ARRIVE 2.0指南/方法学质量/报告质量Key words
precancerous lesions of gastric cancer/TCM compound/animal experiment/SYRCLE tool/ARRIVE 2.0 guideline/methodological quality/reporting quality分类
医药卫生引用本文复制引用
左娇娇,唐晓玲,宋瑞平,豆鹏程,陈心怡,舒劲..基于SYRCLE工具和ARRIVE 2.0指南的中药复方防治胃癌前病变动物实验文献质量评价[J].中国中医药信息杂志,2025,32(1):40-48,9.基金项目
国家自然科学基金(82060860) （82060860）
甘肃省科技计划项目(21JR7RA588) （21JR7RA588）
