转化医学杂志2024，Vol.13Issue(7)：994-999,6.DOI:10.3969/j.issn.2095-3097.2024.07.003
低分子肝素抗凝对慢性阻塞性肺疾病急性加重期患者肺通气、凝血功能和血NLR、PLR、NSE水平的影响
Effects of Low Molecular Weight Heparin Anticoagulation on Pulmonary Ventilation,Coagulation Function,Serum NLR,PLR and NSE Levels in Patients with AECOPD
摘要
Abstract
Objective To investigate the effects of LMWH anticoagulation on pulmonary ventilation,coagulation function,serum neutrophil/lymphocyte ratio(NLR),platelet lymphocyte ratio(PLR)and neuron-specific enolase(NSE)levels in AECOPD patients.Methods 65 AECOPD patients admitted to Meishan people's hospital from June 2022 to March 2024 were included into LMWH group(n=33),subcutaneous injection of LMWH based on routine treatment)and routine group(n=32),routine symptomatic treatment,such as oxygen inhalation and anti-infection)by random number table meth-od.The curative effect was evaluated after 1 week of treatment.Pulmonary ventilation,coagulation function,serum NLR,PLR and NSE were measured before and after 1 week of treatment.Results The total effective rate was significantly higher in the LMWH group(93.94%)compared to the routine group(71.88%)After 1 week of treatment,forced expiratory volume,forced vital capacity,peak expiratory flow rate,arterial partial oxygen pressure and oxygen saturation in the two groups in-creased after treatment,and the LMWH group were higher(P＜0.05),while the partial blood pressure of carbon dioxide(PaCO2)was significantly lower(P＜0.05).After 1 week of treatment,the levels of fibrinogen,D-dimer,serum NLR,PLR and NSE in the two groups decreased after treatment,and the LMWH group was lower(P＜0.05),while activated partial thromboplastin time and prothrombin time were significantly longer(P＜0.05).There was no statistically significant difference in adverse reactions between the two groups(P＞0.05).Conclusion LMWH can significantly improve pulmonary ventila-tion and coagulation function,and reduce serum NLR,PLR and NSE levels in AECOPD patients,which is safe and effective.关键词
慢性阻塞性肺疾病急性加重期/低分子肝素/肺通气/凝血功能/中性粒细胞/淋巴细胞比值/血小板淋巴细胞比值/神经元特异性烯醇化酶Key words
Acute exacerbation of chronic obstructive pulmonary disease/Low molecular weight heparin/Pulmonary ventilation/Coagulation function/Neutrophil/lymphocyte ratio/Platelet lymphocyte ratio/Neuron-specific enolase分类
医药卫生引用本文复制引用
杨婵娟,王贝,吴苏,管弦,李俊,徐维彬..低分子肝素抗凝对慢性阻塞性肺疾病急性加重期患者肺通气、凝血功能和血NLR、PLR、NSE水平的影响[J].转化医学杂志,2024,13(7):994-999,6.基金项目
眉山市科技指导性计划项目(2023KJZD005) （2023KJZD005）
