转化医学杂志2024，Vol.13Issue(7)：1010-1014,5.DOI:10.3969/j.issn.2095-3097.2024.07.006
急性胰腺炎肝素结合蛋白动态分析及基线肝素结合蛋白与患者预后的相关性
Dynamic Analysis of Heparin-Binding Protein in Acute Pancreatitis and the Correlation between Baseline Heparin-Binding Protein and Patient Progno-sis
摘要
Abstract
Objective To analyze the dynamic changes of heparin-binding protein(HBP)in acute pancreatitis(AP)and the correlation between baseline HBP and patient prognosis.Methods 150 patients with AP treated at department of gas-troenterology,Hebei Qinhuangdao first hospital from December 2021 to December 2023 were included,49 cases showed a poor prognosis(poor prognosis group),and 101 cases showed a good prognosis(good prognosis group).Their HBP levels were measured and their prognosis was recorded.Multivariate logistic regression analysis was performed to analyze the independent risk factors for the prognosis of AP patients,and ROC curve analysis was applied to analyze the predictive value of these risk factors in predicting the prognosis of AP patients.Results The level of HBP in two groups patients decreased gradually dur-ing hospitalization;Multivariate logistic regression analysis showed that high HBP level(OR=2.658),high baseline procalci-tonin(OR=2.771),and high baseline C-reactive protein(OR=1.125)were independent risk factors for the prognosis of AP patients(P＜0.05).ROC curve analysis revealed that the optimal cutoff point for HBP level to predict the prognosis of AP patients is 7.400 ng/mL.Conclusion HBP levels in patients with acute pancreatitis gradually decrease during hospitaliza-tion.Baseline HBP levels are independently associated with the prognosis of patients with acute pancreatitis.The best HBP cut-off point for poor prognosis is 7.400 ng/mL.关键词
肝素结合蛋白/急性胰腺炎/治疗反应性/预后Key words
Heparin-binding protein/Acute pancreatitis/Treatment response/Prognosis分类
医药卫生引用本文复制引用
马晓莹,朱芳丽,杨悦,乔红,刘烨,马厉英,韩俊岭..急性胰腺炎肝素结合蛋白动态分析及基线肝素结合蛋白与患者预后的相关性[J].转化医学杂志,2024,13(7):1010-1014,5.基金项目
秦皇岛科学技术研究与发展计划项目(202101A080) （202101A080）
