转化医学杂志2024，Vol.13Issue(8)：1183-1188,6.DOI:10.3969/j.issn.2095-3097.2024.08.009
极早和超早产儿胃肠外营养相关性胆汁淤积症危险因素分析
Retrospective Analysis of Risk Factors for Parenteral Nutrition-associated Cholestasis in Extremely and Ultra Premature Infants
摘要
Abstract
Objective To investigate and analyze the risk factors of parenteral nutrition-related cholestasis(PNAC)in very early and ultra-preterm infants.Methods A total of 196 extremely preterm infants(102 cases)and ultra-preterm in-fants(94 cases)who received parenteral nutrition support for more than 14 days were retrospectively analyzed from January 2018 to December 2022.According to whether the subjects had PNAC or not,they were divided into PNAC group and non-PNAC group.The clinical data of the two groups were compared,and the risk factors of PNAC were analyzed by multivariate logistic regression.Results PNAC occurred in 72 of 196 extremely preterm infants and ultra-preterm infants(36.73%).Compared with non-PNAC group,PNAC group had longer hospital stay,parenteral nutrition duration,amino acid,fat milk,glucose use time,PICC and ventilator duration,higher accumulation of amino acid,fat milk,glucose,parenteral nutrition heat card,and higher incidence of sepsis(P＜0.05,P＜0.01).Compared with non-PNAC group,the proportion of probiot-ics used in PNAC group was lower(P＜0.05).Multivariate logistic regression analysis showed that the duration of parenteral nutrition,cumulative dose of parenteral nutrition heat card,sepsis and ventilator duration were risk factors for PNAC in very early and ultra-preterm infants(P＜0.05).Conclusion Prolonged duration of parenteral nutrition and ventilator duration,increased cumulative use of parenteral nutrition heat cards,and combined sepsis increase the risk of PNAC in very early and ultra-preterm infants.Reasonable control of parenteral nutrition support time and prevention of infection are important meas-ures to reduce PNAC in very early and ultra-premature infants.关键词
胃肠外营养/婴儿,早产/胆汁淤积/危险因素/脓毒症/肠外营养热卡累积用量/呼吸机持续时间/肠外营养持续时间Key words
Parenteral nutrition/Infant,premature/Cholestasis/Risk factors/Sepsis/Cumulative dose of parenter-al nutrition heat card/The duration of the ventilator/Duration of parenteral nutrition分类
医药卫生引用本文复制引用
张景,樊晓莉,王洪青..极早和超早产儿胃肠外营养相关性胆汁淤积症危险因素分析[J].转化医学杂志,2024,13(8):1183-1188,6.基金项目
徐州市儿童医院科研项目(22040431) （22040431）
